Draw a model for the conformational states of glyceraldeyde-3-P dehydrogenase, a tetrameric enzyme displaying negative cooperativity
Glyceraldehyde-3-phosphate dehydrogenase catalyzes the synthesis of 1,3-bisphosphoglycerate:
Glyceraldehyde-3-P + Pi + NAD+ ⇌ 1,3-BPG + NADH + H+
The enzyme is a tetramer. NAD+ binding shows negative cooperativity. Draw a diagram of possible conformational states for this tetrameric enzyme and its response to NAD+ binding that illustrates negative cooperativity.
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