In bacteriophages and bacteria, the DNA is almost al-ways organized into circular (dosed loops) chromosomes. Phage A is an exception, maintaining its DNA in a linear chromosome within the viral particle. However, as soon as this DNA is injected into a host cell, it circularizes before replication begins. What advantage exists in replicating circular DNA molecules compared to linear molecules, characteristic of eukaryotic chromosomes?
HINT: This problem involves an understanding of eukagotic DNA replication, as discussed in Chapter 11. The key to its solution is to consider why the enzyme telomerase is essential in eukaryotic DNA replication, and why bacterial and viral chromosomes can be replicated without encountering the "telomere" problem.
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