The HIV is a subgroup of retrovirus and causes infection of HIV as well as after some time leads to AIDS (acquired immunodeficiency syndrome). A situation affects humans as well as results in progression of failure of the human immune system.
HIV protease deals with the long strands of the RNA (ribonucleic acid) of the virus. The RNA is cleaved in the presence of proteases. These drugs act via cleaving of protein precursors that are important for the assembly of infectious viral particles.
L-685434 is one of the potent inhibitor of protease. It consists of 1-amino and 2-hydroxyindan ligand and is involved in blocking of HIV. L-685434 acts as a selective HIV inhibitor. It also acts as an inhibitor of Alzheimer’s disease.
IC50 is the downhill dose of any drug that is used to show an inhibitory response at the level of 50%. It is applied to inhibit a specified target. These targets involve a reduction in the activity of luciferase assay used for a particular protein and any isolated enzyme.