Problem

Geneticists often use ethylmethane sulfonate (EMS) to induce mutations in Drosophila. Wh...

Geneticists often use ethylmethane sulfonate (EMS) to induce mutations in Drosophila. Why is EMS a mutagen of choice for genetic research? What would be the effects of EMS in a strain of Drosophila lacking functional mismatch repair systems?

¦ HINT: This problem asks you to evaluate EMS as a useful mutagen and to determine its effects in the absence of DNA repair. The key to its solution is to consider the chemical effects of EMS on DNA. Also, consider the types of DNA repair that may operate on EMS-mutated DNA and the efficiency of these processes.

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