Question

Termination of neurotransmiss ion: Parasympathetic (cholinergic) neurotransmission vs Sympathetic (adrenergic) neurotransmission. What type of receptors are adrenergic receptors? Differentiate the function of presynaptic autoreceptors vs presynaptic heteroreceptors? What does it mean, in general, if a drug is a direct vs an indirect agonist? Which drug did we discussed is a partial agonist and persistent antagonist on a4B2 nicotinic receptors in the CNS? What is the mechan ism of action of donepezil and other drugs in its class for treatment of Alzheimer's?

Answer 1

types of receptors are adrenergic receptors;

• Alpha 1.
• alpha 2.
• beta 1.
• beta 2.
• beta 3.

1. aplha 2 has presynaptic and postsynapyic .
2. beta 1 present in heart and kidney,
3. beta 2 present in bronchial smooth muscle,uterus,skeletal muscles,detrusor muscle and liver.
4. beta 3 present in adipose tissue.
5. alpha 1 present in vascular,muscle of iris and anal sphincter.
6. alpha 2 present in presynaptic,smooth muscle and brain stem.

differentiate function of presynaptic autoreceptors and presynaptic heteroreceptors:

Presynaptic autoriceptor Heteroreceptor CD is a recepter la sensitive to situated & Theat Tera Neurotransmitters Terminal of an noir na and hormones, That presynaptic nerve in are not released by cell, That is zersitive The cell on which it sett to Neurotransmitters * receptor regulating released by neerron The synthesis other than й whо е момеаи its own ligand autorecepter die e in