Question

M.W. is a 52 year old white female. She has been prescribed Conjugated Estrogen- Premarin as a result of recent studies that show she is experiencing early signs of menopausal osteoporosis. She is also taking an oral calcium supplement with Vitamin D, as well as a multivitamin.What class of medication is Conjugated Estrogen (Premarin) and how does it work?

What instructions should you give the client on the Premarin?

What are the adverse effects of this medication?

What are "Black Box Warnings"? What are the specific warnings for Premarin?

What is the purpose of the oral calcium supplement? Of the Vitamin D?

Answer 1

1. Premarin is medication contains conjugated estrogen(Mixture of hormone estrogen), Estrogen is a female hormone which secreted by ovaries.

It is mainly used for hormonal replacement, Menopause, Osteoporosis and any other hormonal disturbances in the female.

2.. Premarin is a hormonal medication, it can interact with a lot of medications. Tell the client to don't use any over the counter medication without a prescription.

This medication increases the risk of blood clots in the blood vessels, advise the client to avoid any other trigger related to the blood clot. Ex - Smoking

Grapes and Grapefruit juice may interact with Premarin medication so, advice to avoid it.

3. Adverse effects of this medication include

• Severe vaginal bleedings
• Pelvic pain
• Abdominal pain
• Indigestion and constipation
• Symptoms of Heart attack
• Symptoms of Stroke
• Jaundice

4. There are 2 Black box warnings for  Premarin

• Heart disease and Stroke (Because it increases the risk of blood clots in the blood vessels)
• Uterine cancer (It is a hormonal medication, it may cause changes in uterine linings.

5. To reduce the symptoms of osteoporosis She is taking an oral calcium supplement with Vitamin D.