How can the NMP oxalate salt be converted back to NMP?
Here is the procedure:
PROCEDURES
Part A: Synthesis of (±)-N,N-dimethyl-3-phenyl-3-(4-trifluoromethylphenoxy)propanamine
Part B: Synthesis of the Oxalate Salt of NMP
How can the NMP oxalate salt be converted back to NMP? Here is the procedure: PROCEDURES...
Propose another way of synthesizing NMP from the amino ketone hydrochloride salt starting material you used. Part A: Synthesis of (t)-N,N-dimethyl-3-phenyl-3-(4- trifluoromethylphenoxy)propanamine 1. To the 250-mL round-bottom flask (RBF) containing (t)-3-(dimethylamino)-1-phenylpropanol (product from Lab 6) and a magnetic stir bar, add 4 mL of 4- chlorobenzotrifluoride and 30 mL of dimethylacetamide (DMA) 2. With stirring, add to this mixture 30 mL of 1.0 M potassium tert-butoxide (caustic alkali!) in tert-butyl alcohol using a syringe 3. Using a simple distillation apparatus,...
The alcohol could easily be converted to a tosylate, a good leaving group, and a conventional substitution reaction could have been performed instead of the nucleophilic aromatic substitution (NAS) reaction. Why was the NAS reaction the preferred method? (Hint : Look up the nucleophiles of both reactions on chemical manufacturing site.) Part A: Synthesis of (t)-N,N-dimethyl-3-phenyl-3-(4- trifluoromethylphenoxy)propanamine 1. To the 250-mL round-bottom flask (RBF) containing (t)-3-(dimethylamino)-1-phenylpropanol (product from Lab 6) and a magnetic stir bar, add 4 mL of 4-...
The alcohol could easily be converted to a tosylate, a good leaving group, and a conventional substitution reaction could have been performed instead of the nucleophilic aromatic substitution (NAS) reaction. Why was the NAS reaction the preferred method? (Hint : Look up the nucleophiles of both reactions on chemical manufacturing site.) Part A: Synthesis of (t)-N,N-dimethyl-3-phenyl-3-(4- trifluoromethylphenoxy)propanamine 1. To the 250-mL round-bottom flask (RBF) containing (t)-3-(dimethylamino)-1-phenylpropanol (product from Lab 6) and a magnetic stir bar, add 4 mL of 4-...
QUESTION: Show the mechanism of the reduction of 3-dimethylaminopropiophenone hydrochloride to form the alcohol? PROCEDURE: Add 2.00 g of 3-dimethylaminopropiophenone hydrochloride, 10 mL of distilled water and a magnetic stir bar to a 100 mL beaker, and stir to dissolve. This is the reaction beaker. Add (with stirring) sufficient 10% NaOH (about 5–6 mL) to bring the solution to pH >10. The free base will form and come out of solution as a milky oil. With continued stirring, add enough...
3) The hydrogen atom in HCl is electrophilic whereas the hydrogen atoms in sodium borohydride are nucleophilic. Offer a plausible rationale for this difference in reactivity. PROCEDURES 1. Add 2.00 g of 3-dimethylaminopropiophenone hydrochloride, 10 mL of distilled water and a magnetic stir bar to a 100 ml beaker, and stir to dissolve. This is the reaction beaker. 2. Add (with stirring) sufficient 10% NaOH (about 5-6 mL) to bring the solution to pH > 10. The free base will...
noinizdle dn Draw a flow sheet to describe the separation procedure. (10 pts) doprleoudenagne aded 6. Are several small-scale extractions more efficient than one large-scale extraction? Why? (10 pts) 7. Why the upper layer should be poured out from the top of the separatory funnel but not be drained from the stopcock? (10 pts) Extraction: Separation of a Neutral and Basic Substances 1 Dissolve 2 g of a mixture of naphthalene and 4-chloroaniline in 20 mL of ethyl ether and...
SYNTHESIS OF T-PENTYL CHLORIDE LAB Provide a stoichiometry table for the reaction being performed in this lab. PROCEDURE Preparation oft-Pentyl Chloride In a 125-mL separatory funnel, place 10.0 mL of tert-pentyl alcohol (2-methyl-2- butanol, MW = 88.2, d = 0.805 g/mL) and 25 mL of concentrated hydrochloric acid (d 1.18 g/mL). Do not stopper the funnel. Gently swirl the mixture in the separa- tory funnel for about 1 minute. After this period of swirling, stopper the separatory funnel and carefully...
Thumbs up for good answer. Why does the liquid in the round bottom flask turn light pink?, please explain (This happened during/after step 2). This is the procedure and the experiment is called Synthesis of Artificial Flavorings by Fischer Esterification. Thank you! SAMPLE PROCEDURES: 1. Isoanvl acetate (banana) + H2O OH HO 1. Mix 6 mL of isoamyl alcohol (0.809 g/mL, 88.148 g/mol) and 10 ml ofglacial acetic acid (1.05 g/ml 60.05 g/mol) in a 100 mL round bottom flask....
What is the reaction product(s) of oleic acid & sodium methoxide? Show the structure(s). Part A: Acid Catalyzed Fischer Esterification of Free Fatty Acids Add 20 mL of canola oil and a magnetic stir bar to a 125-mL Erlenmeyer flask, and place the flask on a magnetic stirring plate. Add 2–3 mL of methanol and up to three drops of concentrated sulfuric acid Perform this step with caution, as this is a strong acid! Immerse a thermometer into the reaction...
QUESTION: Write a flow scheme for the work-up. THE WORK UP: C. Work-up (save all layers) and Isolation of Product MgBrCl Benzoic acid Transfer the mixture into a test tube. Rinse the beaker with about 3 mL of regular (not anhydrous) diethyl ether and pour the washings into the test tube. There should be two distinct layers in the test tube Remove the aqueous layer (to be discarded) and shake the ether layer with about 2 mL of 3 M...