Question

PN 105 Fundamentals of Nursing I Amikacin - Aminoglycoside JN, a 46-year-old woman, has a wound infection. The culture report stated that the infection was caused by pseudomonas aeruginosa and that JN's temperature was 104F Amikacin sulfate (Amikin) is to be administered IV in 100 mL of D5/W over 45 minutes every 8 hours. The dosage is 15mg/kg/day in three divided doses. JN weighs 165 pounds. 1. What is the drug classification of amikacin? 2. How many milligrams of amikacin should JN receive every 8 hours? 3. What type of IV infusion should be used? Explain your answer. 4. When would a wound culture be obtained to determine the appropriate antibacterial agent? Explain your answer. 5. What are the similarities of amikacin to other aminoglycosides such as gentamicin? 6. Would one aminoglycoside be preferred over another? Explain your answer. The nurse assesses JN for hearing and urinary function before and during amikacin therapy. 7. What should a hearing assessment include? 8. JN's urine output in the last 8 hours was 125 mL. Explain the possible cause for the amount urine output. 9. Prepare a list of at least six (6) nursing interventions that should be taken.

Answer 1

1. Amikacin belings to aminoglycoside group of antibiotics

2. Wt 165 lbs=74.8 ~75 kg

recommended dose 15 mg/kg/day

for JN, total dose=15*75=1125 mg/ day

per dose=1125/3=375 mg

4. wound culture should be taken before starting any antimicrobial therapy as antibiotic treatment can affect the microbiological study

5. Both aminoglycosides bind to the 30S ribosome, thereby inhibiting bacterial protein synthesis.

they both have affect on human fetus.

they both are not available for oral route. Preferred route is intravascular route.

6. Yes, there are certain cases when one aminoglycoside is preferred over other for example Amikacin, however, is not degraded by the common enzymes that degrade gentamicin and often shows broader antimicrobial spectrum than gentamicin. Amikacin is thus the preferred agent when refractory or nosocomial infections caused by resistant strains of Klebsiella spp and P. aeruginosa are encountered.

7.hearing assessment include rinne and weber test which compare bone and air conduction . In patients taking amikacin, they may have hearing loss or other signs of ototoxicity