Cystic fibrosis is a hereditary disorder affecting the exocrine
glands
results in the production of abnormally thick mucous
blockage of the pancreatic ducts,intestines,and the bronchi
respiratory infection
Cystic fibrosis is a genetic or hereditary disease.
*The gene responsible for the cystic fibrosis is defective CF gene.
*The people with Cystic fibrosis have inherited two copies of defective CF gene.ie one copy from each parent.Here in this case both the parents must have atleast one copy of defective CF gene.
*If people with only one copy of defective CF gene are called as carriers,They dont have the disease but they will act as carrier,means he/she has inherited a genetic trait or mutation but displays no symptoms of the disease.
*Any way the carriers of the cystic fibrosis will not exhibit any symptoms,but can pass the non-functioning gene on to their children.
*If in case each time two CF carriers have a child,the chances of having a child with cystic fibrosis is 25% (1 in 4 child may present cystic fibrosis).
*The defective CF gene having an abnormality called as mutation/gene mutation
Describe strategies to delete the Cystic Fibrosis gene and to replace a mutant Cystic Fibrosis gene with a fully functional gene in human cells using the CRISPR/Cas9 system.
Cystic fibrosis is an autosomal recessive disease caused by a mutation in a single gene with two alleles. Suppose the frequency of cystic fibrosis in a population is 3%. Assuming the gene is in HW equilibrium, calculate the allele and genotype frequencies. If the population consists of 100 individuals, how many are carriers (but unaffected) for the cystic fibrosis allele?
What role did genetic linkage play in ultimately identifying the gene for cystic fibrosis?
The location for the gene for cystic fibrosis is 7q31.2. This means that the gene is located on a. On the short arm of chromosome 3 at position 79 b. the long arm of chromosome 7 at position 31.2. c. On the long arm of chromosome 3 at position 70 d. On the long arm of chromosome 2 at position 319. e, the short arm of chromosome 7 at position 31.2
what gene abnormality cause cystic fibrosis? Definition of carcinoma in situ? what are tumor cell marker? hypersensitivity reactions and the dermis what happens?
Parents who do not have cystic fibrosis (recessive) produce a child who has cystic fibrosis. What are the chances that each child born to this couple will have cystic fibrosis? 100% 75% 25% 0% All of the choices are correct. Could a man with blood type A father a child with blood type B? No, only males with type B or AB can have children with type B blood. Yes, if his genotype was AO and the mother had type...
Glandular secretions are abnormally high in children with cystic fibrosis. The gene responsible is recessive to the gene for normal secretions. What are the possible phenotypes in a cross between two heterozygous individuals? One heterozygous and one homozygous normal? please explain :-) thanks
Cystic fibrosis gene is 300,000 base pairs long. The transcribed portion of the gene spans 250,000 base pairs of DNA. The cytoplasmic mRNA for this gene is 6500 bases long. The protein is 1480 amino acids long. The sum of bases coding for introns is approximately:
Propose a NOVEL therapeutic idea based on gene therapy cell and molecular mechanisms for cystic fibrosis
(3 parts for the answers) Cystic Fibrosis Cystic fibrosis is an autosomal recessive disorder that affects 1 in 3 000 newborns with a Caucasian background. It causes thick mucus build up in various organs and can cause damages and problems in respiratory and digestive systems. --What is the frequency of the cystic fibrosis allele in the Caucasian population? Show all your work and express your answer as a value between 0 and 1 rounded to two decimal places --What percentage...