Question

What role did genetic linkage play in ultimately identifying the gene for cystic fibrosis?

Answer 1

QUESTION-1

ANSWER

CYSTIC FIBROSIS

• Cystic fibrosis is a serious genetic condition that causes severe damage to the respiratory and digestive systems.
• Thick, sticky mucus in the organs builds up.
• Most affected organs are lungs, pancreas, small intestine, and liver.
• Instead of acting as a lubricant, the fluids clog the ducts, tubes, and passageways in the body.
• There is currently no cure for Cystic fibrosis.
• People with the cystic fibrosis tend to have a shorter-than-normal life span.

The symptoms of Cystic fibrosis-

• salty-tasting skin,
• persistent coughing,
• shortness of breath,
• wheezing,
• poor weight gain in spite of excessive appetite,
• greasy, bulky stools,
• nasal polyps, or small, fleshy growths found in the nose,
• Constipation,
• nausea,
• a swollen abdomen,
• loss of appetite,
• poor weight gain in children,
• delayed growth in children.

The role genetic linkage play in ultimately identifying the gene for cystic fibrosis-

Cystic Fibrosis is primarily caused by genetic mutations that take place in the cystic fibrosis transmembrane conductance regulator, commonly referred to as the CFTR gene.

The CFTR gene has a role to play in the production of CFTR proteins.

When these CFTR proteins function as they should, this regulates the usual transport of the salt and fluids to and fro from the cells.

In order to develop cystic fibrosis, the child has to inherit both mutated copies of this CFTR gene, one from each parent.

CFTR modulators are used to treat Cystic fibrosis.

We can clone cystic fibrosis gene by positional cloning: on the basis of map location.CF was the first genetic disorder elucidated strictly by positional cloning.

Cystic fibrosis used genetic mapping to determine where the CFTR gene was located in order to identify and treat them.

GOOD LUCK.