A 60 kg asthmatic has been receiving aminophylline (S=0.8) by infusion at 50 mg/hr. A steady...
A 60 kg asthmatic has been receiving aminophylline (S=0.8) by infusion at 50 mg/hr. A steady state theophylline level is drawn and reported as 8 mg/L. The patient is still wheezing, but now is ready to take the medication orally. The physician wishes to use oxtryphylline (s=0.65, F=1) q6hrs and increase the average Cpss to 14 mg/L to improve the patient status
a). What exact dose of oxtryphylline should be given?
b). What actual dose of oxtryphylline should be given?
c). What is the expected average Cpss on the dose used in part b?
Homework Answers
The patient weight is 60 kg. We need to calculate theophylline clearance value and then portion the oxtryphylline dose (R0) to achieve the 8mg / LC concentration.
Add Answer to:
A 60 kg asthmatic has been receiving aminophylline (S=0.8) by
infusion at 50 mg/hr. A steady...
Hendeles and Weinberger further state an infusion of 0.85 mg/kg/hr of theophylline will produce an eventual...
Hendeles and Weinberger further state an infusion of 0.85 mg/kg/hr of theophylline will produce an eventual plasma theophylline concentration of 10 mcg/ml in children 1-9 years old (plasma concentrations, however, should be monitored after 12-24 hours to avoid toxicity). a) If Hendeles and Weinberger are correct about the Cpss of 10mcg/ml, what would be the K and t1/2 in this example child? (b) What infusion rate (Ro) of aminophylline should therefore be given to a 3-year-old. 15 kg child to...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
Calculation problem 4: nonlinear PK, phenytoin dosing A 70-kg patient has been taking phenytoin 250 mg...
Calculation problem 4: nonlinear PK, phenytoin dosing A 70-kg patient has been taking phenytoin 250 mg per day for 4 months. His plasma drug level averaged 5 mg/L on this dose. Adjustment in dose to 500 mg per day eventually led to a new plateau level of 25 mg/L. The volume of distribution of phenytoin is 0.65 L/kg. 1) Use a graphical method to estimate the patient's Vma/F and K values. 2) Estimate a daily dose which should provide a...
1. Your patient weighing 44 lbs has an order for Tylenol (acetaminophen) 325 mg stat. The...
1. Your patient weighing 44 lbs has an order for Tylenol (acetaminophen) 325 mg stat. The recommendations for acetaminophen is 10 - 15 mg/kg/dose. Tylenol solution is available is 160mg per teaspoon. A. Is this ordered dose safe? B. How many mls would you give 2. A child has an order for ibuprofen 185 mg orally prn q6h. Ibuprofen solution is available as 100 mg tsp. How many ml do you need for this dose? 3. A client weighing 110...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
Name: 7. A patient with asthma was recently diagnosed with glaucoma. Which of the following drugs...
Name: 7. A patient with asthma was recently diagnosed with glaucoma. Which of the following drugs should the consider as relatively safe for the patient? a. LABAS b. Xanthine derivatives c. SABAs d. Inhaled corticosteroids A patient is prescribed aminophylline for systematic relief of bronchial asthma. The nurse is required to inform the patient about other drugs that may interact with aminophylline. Which of the following drug increases the effects of aminophylline? Ketoconazole b. Rifampin c. Loop diuretics d B-blockers...
PN 200 Fundamentals of Nursing II Upper & Lower Respiratory Drugs Multiple Choice Identit the choice...
PN 200 Fundamentals of Nursing II Upper & Lower Respiratory Drugs Multiple Choice Identit the choice that best completes the statement or swers the question 1. A patient has purchased a nasal decongestant for all members of the household to use. Which of the following instructions is a priority for the nurse to educate the patient about the drug? a. Topical decongestants can sting or burn when used. b. Rebound congestion can occur with topical decongestants c. Do not allow...
Convert the following:show your work(1 point each) 10-kilograms equals _____ pounds 12.5 ml is equal to...
Convert the following:show your work(1 point each) 10-kilograms equals _____ pounds 12.5 ml is equal to _____ teaspoons 45 ml is equal to _____ Tablespoons 4 tsp is equal to _____ ml 3 Tbsp is equal to _______ounces 0.1 grams is equal to _______ mcg 1 cup is equal to ____ounces 1 liter is equal to _____ ml 3 Tbsp is equal to ___ tsp 75 lbs.is equal to _____kg. 9 oz is equal to _______ml 38 degrees Celsius is...
The nurse is counseling a client with a poor appetite and weight loss. Which priority intervention...
The nurse is counseling a client with a poor appetite and weight loss. Which priority intervention should the nurse recommend? Eat your favorite foods to get additional calories, no matter what they are. Consume high protein, high-calorie replacement drinks between meals. Take a daily vitamin. Eat 6 small meals each day. A client is prescribed a diet that can be advanced as tolerated. How does the nurse recognize that the client is ready to be started on regular food? Select...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
Calculation problem 4: nonlinear PK, phenytoin dosing A 70-kg patient has been taking phenytoin 250 mg per day for 4 months. His plasma drug level averaged 5 mg/L on this dose. Adjustment in dose to 500 mg per day eventually led to a new plateau level of 25 mg/L. The volume of distribution of phenytoin is 0.65 L/kg. 1) Use a graphical method to estimate the patient's Vma/F and K values. 2) Estimate a daily dose which should provide a...
1. Your patient weighing 44 lbs has an order for Tylenol (acetaminophen) 325 mg stat. The recommendations for acetaminophen is 10 - 15 mg/kg/dose. Tylenol solution is available is 160mg per teaspoon. A. Is this ordered dose safe? B. How many mls would you give 2. A child has an order for ibuprofen 185 mg orally prn q6h. Ibuprofen solution is available as 100 mg tsp. How many ml do you need for this dose? 3. A client weighing 110...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
Name: 7. A patient with asthma was recently diagnosed with glaucoma. Which of the following drugs should the consider as relatively safe for the patient? a. LABAS b. Xanthine derivatives c. SABAs d. Inhaled corticosteroids A patient is prescribed aminophylline for systematic relief of bronchial asthma. The nurse is required to inform the patient about other drugs that may interact with aminophylline. Which of the following drug increases the effects of aminophylline? Ketoconazole b. Rifampin c. Loop diuretics d B-blockers...
PN 200 Fundamentals of Nursing II Upper & Lower Respiratory Drugs Multiple Choice Identit the choice that best completes the statement or swers the question 1. A patient has purchased a nasal decongestant for all members of the household to use. Which of the following instructions is a priority for the nurse to educate the patient about the drug? a. Topical decongestants can sting or burn when used. b. Rebound congestion can occur with topical decongestants c. Do not allow...
Most questions answered within 3 hours.
-
According to the network system security, please explain:
1- What is canary and how it does...
asked 1 hour ago -
Study the provided BagInterface and the methods implemented in
the ResizableArrayBag
For the following methods that...
asked 1 hour ago -
Enter your answer in the provided box. To what fraction of its
original volume, Vfinal/Vinitial, must...
asked 1 hour ago -
Can you figure out if any R functions used to subset a time
series 1 or...
asked 2 hours ago -
Which of the following is correct?
A. APC + MPS = 1
B. APS + MPS...
asked 2 hours ago -
Given a regression sum of squares equal to 2373.59 and a total
sum of squares equal...
asked 3 hours ago -
Compare and contrast the linear motion and angular motion
equations F ma and . That is,...
asked 3 hours ago -
Now that this course has taken you on a journey of introduction
to the world of...
asked 3 hours ago -
The sandwich maker of the EE-Cole-Eye Sandwich Truck was just
fired (for a reason described below)...
asked 6 hours ago -
Name the following coordination compounds using systematic
nomenclature.
1. [Co(H2O)6]Cl2:
2. [Cr(NH3)6](NO3)3:
3. K4[Fe(CN)6]:
4. Na[Au(CN)4]:...
asked 5 hours ago -
Propose an efficient synthesis of 2-Bromo-5-nitrotoluene from
benzene. Hint: 3 steps. Consider directing effects of substituents....
asked 7 hours ago -
This assignment will explore the impact of corporate decisions
on a local versus a global perspective....
asked 6 hours ago