Homework Answers
Our answer is (d)
All c-c bond coupling reaction s are which catalised by transition metal involve in identical mechanism steps.
1) Oxidative addition
2) Beta-hydride transfer/elimination/Transmetallation
3) Reductive elimination
In the following order. Some examples
Suzuki coupling,heck reaction, sonagasira coupling
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· (4 pts) Which of the following transition metal reactions is un owing transition metal reactions...
Please give a detailed explanation. 18.15 The Wilkinson catalyst chlorotris(triphenylphosphine)rhodium(I), CIRh(PPha), brings about the catalytic hydrogenation...
Please give a detailed explanation.
18.15 The Wilkinson catalyst chlorotris(triphenylphosphine)rhodium(I), CIRh(PPha), brings about the catalytic hydrogenation of an alkene in homogeneous solution: R R CIRh(PPh3)3 C=C + H - RCH CHR (18.41) HH (a) Using the following mechanistic steps as your guide, draw structures of the transition-metal complexes involved in each step. Give the electron count and the metal oxidation state at each step. 1. oxidative addition of H, to the catalyst 2. ligand substitution of one PPhz by the...
UESTION 1 Consider the following five transition metal complexes A - E: PPhz CO CO Cl...
UESTION 1 Consider the following five transition metal complexes A - E: PPhz CO CO Cl В PPh3 CO Cl/ CH CH CH 2 Ph2P 2 143 CO CO CH a) Assign electron count and formal oxidation states to each of the five complexes b) Which of the complexes (if any) are likely to undergo the following types of reaction? In each case, give the main product expected (i)Oxidative addition (ii)1,2 insertion ("alkene" insertion) (iii) Reductive elimination
5. Heck Reactions: Consider the following reaction: Pd atalyst yº syn-elimination of HPI T trars-configuration of...
5. Heck Reactions: Consider the following reaction: Pd atalyst yº syn-elimination of HPI T trars-configuration of double bond a) The configuration of the double bond in the above reaction is predominately trans. This can be explained by drawing a Newman projection of the intermediate in the brackets. The elimination of HPdI is syn (from the same side), An eclipsed conformation is required. - Please complete the partially drawn Newman below by replacing the question marks by the missing phenyl group...
13. (4 pts) Which of the following Newman projection represents the confirmation prior to B-hydrogen elimination...
13. (4 pts) Which of the following Newman projection represents the confirmation prior to B-hydrogen elimination of HA during a Heck reaction? Ph Ph Hex Ph H3C YNH Нас- Нусун Ph не POLX H. POLX H POLX POLX 14. (4 pts) If you determine the rate limiting step of your catalytic cycle is the oxidative addition when Pd(PCys) is used, which ligand would you chose to replace PCys so the reaction rate increases? a. PPh b. P(OPh)3 c. P(t-Bu); d....
un 1. Both of the following reactions use tertiary amine catalysts in their transformations to accomplish...
un 1. Both of the following reactions use tertiary amine catalysts in their transformations to accomplish interesting new carbon-carbon bond forming reactions. So, let's compare them by providing a detailed mechanism for the transformations below. Include all curved arrows, reaction arrows, reaction intermediates, formal charges, and any other relevant details. Resonance forms are not required. TIP: The amine catalyst is very nucleophilic. I would start with using it in a Michael addition. Feel free to abbreviate the amine as R3N....
Name: 4. Put the following reactions in the order they occur in elycolysis. Indicate reactions do...
Name: 4. Put the following reactions in the order they occur in elycolysis. Indicate reactions do not occur (exactly in reverse) in the gluconeogenic pathway and also which steps are likely to be catalyzed by a highly regulated enzyme. Also indicate which step would "back up" under anaerobic conditions if fermentation did not occur (16 pts) (a) Dehydration of 2-Phosphoglycerate to form PEP (b) Phosphorylation of Fructose-6-Phosphate to form Fructose-1,6-bis- Phosphate (c) 1,3-Phosphoglycerate reacts with ADP to generate ATP (d)...
1-24 need help really lost Proton Transfer: deprotonation D. 1) Add the appropriate curved arrows for...
1-24 need help really lost
Proton Transfer: deprotonation D. 1) Add the appropriate curved arrows for the following deprotonation step. Also add the other product notice how the Tema s can be converted to this by use of a strong base such as sodium a sodium ion (Na) is not drawn, in this case it is just a spectatorio PCW27 - Mechanistic steps - Part Name: Time spent 2) Label the above compounds with the appropriate name from the previous...
Please completely answer the questions, thank you! For the reactions below, 1. supply the reagents needed...
Please completely answer the questions, thank you!
For the reactions below, 1. supply the reagents needed to carry out the reaction, by writing them above the reaction arrow. 2. Use choices 1A through 11, 2A through 24, and 3A through 3X, above to answer the questions about reaction types and mechanistic details. 3. For the reactions in column 3, that require you to diagram the mechanism, diagram the mechanism. Column 1 Column 2 Column 3 Type of Reaction The Reason...
1. [10 pts] Consider the elimination reaction for the following alkyl halide with sodium methoxide in...
1. [10 pts] Consider the elimination reaction for the following alkyl halide with sodium methoxide in methanol (Na* OCH, CH,OH). CH NaOme MeOH CH Compound A Problem 2c Draw the major expected organic product (a) Redraw Compound A as seen in Viewpoint I below left as a Newman projection on the template provided in Problem 2a (below). Hint: Fill in missing Hs ar C2 and C3 to help you get started! (b) Rotate the C2 C3 bond to obtain the...
Multiple Choice (2 pts each) 6: Calculate the pH of a buffer containing 0.010 M lactic...
Multiple Choice (2 pts each) 6: Calculate the pH of a buffer containing 0.010 M lactic acid (pK,-3.86) and 0.050 M sodium lactate 1: The aqueous environment of cells: A. Is generally irrelevant to biochemical structures and processes B. Serves as a source of energy for biochemical A. 3.16 B. 4.56 processes С. 3.82 D. 3.9 C. Provides an appropriate context for polar molecules and H-bonding that are critical for life D. Allows biochemical molecules to move freely in solution...
Please give a detailed explanation.
18.15 The Wilkinson catalyst chlorotris(triphenylphosphine)rhodium(I), CIRh(PPha), brings about the catalytic hydrogenation of an alkene in homogeneous solution: R R CIRh(PPh3)3 C=C + H - RCH CHR (18.41) HH (a) Using the following mechanistic steps as your guide, draw structures of the transition-metal complexes involved in each step. Give the electron count and the metal oxidation state at each step. 1. oxidative addition of H, to the catalyst 2. ligand substitution of one PPhz by the...
UESTION 1 Consider the following five transition metal complexes A - E: PPhz CO CO Cl В PPh3 CO Cl/ CH CH CH 2 Ph2P 2 143 CO CO CH a) Assign electron count and formal oxidation states to each of the five complexes b) Which of the complexes (if any) are likely to undergo the following types of reaction? In each case, give the main product expected (i)Oxidative addition (ii)1,2 insertion ("alkene" insertion) (iii) Reductive elimination
5. Heck Reactions: Consider the following reaction: Pd atalyst yº syn-elimination of HPI T trars-configuration of double bond a) The configuration of the double bond in the above reaction is predominately trans. This can be explained by drawing a Newman projection of the intermediate in the brackets. The elimination of HPdI is syn (from the same side), An eclipsed conformation is required. - Please complete the partially drawn Newman below by replacing the question marks by the missing phenyl group...
13. (4 pts) Which of the following Newman projection represents the confirmation prior to B-hydrogen elimination of HA during a Heck reaction? Ph Ph Hex Ph H3C YNH Нас- Нусун Ph не POLX H. POLX H POLX POLX 14. (4 pts) If you determine the rate limiting step of your catalytic cycle is the oxidative addition when Pd(PCys) is used, which ligand would you chose to replace PCys so the reaction rate increases? a. PPh b. P(OPh)3 c. P(t-Bu); d....
un 1. Both of the following reactions use tertiary amine catalysts in their transformations to accomplish interesting new carbon-carbon bond forming reactions. So, let's compare them by providing a detailed mechanism for the transformations below. Include all curved arrows, reaction arrows, reaction intermediates, formal charges, and any other relevant details. Resonance forms are not required. TIP: The amine catalyst is very nucleophilic. I would start with using it in a Michael addition. Feel free to abbreviate the amine as R3N....
Name: 4. Put the following reactions in the order they occur in elycolysis. Indicate reactions do not occur (exactly in reverse) in the gluconeogenic pathway and also which steps are likely to be catalyzed by a highly regulated enzyme. Also indicate which step would "back up" under anaerobic conditions if fermentation did not occur (16 pts) (a) Dehydration of 2-Phosphoglycerate to form PEP (b) Phosphorylation of Fructose-6-Phosphate to form Fructose-1,6-bis- Phosphate (c) 1,3-Phosphoglycerate reacts with ADP to generate ATP (d)...
1-24 need help really lost
Proton Transfer: deprotonation D. 1) Add the appropriate curved arrows for the following deprotonation step. Also add the other product notice how the Tema s can be converted to this by use of a strong base such as sodium a sodium ion (Na) is not drawn, in this case it is just a spectatorio PCW27 - Mechanistic steps - Part Name: Time spent 2) Label the above compounds with the appropriate name from the previous...
Please completely answer the questions, thank you!
For the reactions below, 1. supply the reagents needed to carry out the reaction, by writing them above the reaction arrow. 2. Use choices 1A through 11, 2A through 24, and 3A through 3X, above to answer the questions about reaction types and mechanistic details. 3. For the reactions in column 3, that require you to diagram the mechanism, diagram the mechanism. Column 1 Column 2 Column 3 Type of Reaction The Reason...
1. [10 pts] Consider the elimination reaction for the following alkyl halide with sodium methoxide in methanol (Na* OCH, CH,OH). CH NaOme MeOH CH Compound A Problem 2c Draw the major expected organic product (a) Redraw Compound A as seen in Viewpoint I below left as a Newman projection on the template provided in Problem 2a (below). Hint: Fill in missing Hs ar C2 and C3 to help you get started! (b) Rotate the C2 C3 bond to obtain the...
Multiple Choice (2 pts each) 6: Calculate the pH of a buffer containing 0.010 M lactic acid (pK,-3.86) and 0.050 M sodium lactate 1: The aqueous environment of cells: A. Is generally irrelevant to biochemical structures and processes B. Serves as a source of energy for biochemical A. 3.16 B. 4.56 processes С. 3.82 D. 3.9 C. Provides an appropriate context for polar molecules and H-bonding that are critical for life D. Allows biochemical molecules to move freely in solution...
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