Question

Predict the effects on a patient if the levels of opsonin change o identify the cells that produce complement proteins o Indicate where complement proteins are located in a healthy person o Indicate the type of enzyme needed to activate complement proteins o Indicate the three different ways to activate complement system and the ultimate result of those pathways. (Is it different? Or the same?) o Draw a simple graph to demonstrate the difference in levels between C3, C3a and C3b when a person is healthy vs. when a person has an acute infection o Use a labeled drawing to contrast the role of C3a vs. C3b on phagocytic cells

Answer 1

1. Complement system and proteins are mostly produced by hepatocytes but some amount of these substances are also produced by eithilial cells, macrophages and monocytes.

2. Complement substances are several small substances that are produced by liver and regulates in blood as precurssors. These proteins are found in blood in cells such as hepatocytes, macrophages and monocytes and are activated by enzymes.

3. Most of the complementary proteins are proteases and are activated through protelytic cleavage system, the enzyme proteases is mainly responsible for the activation of complementary proteins.

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