Question

18. Cefazolin is a commonly used intravenous antibiotic in veterinary patients. It is typically administered slowly over a 20 minute period because rapid administration causes vomiting in most patients. How many grams of cefazolin are in this unreconstituted bottle? Qrom Coro etazolin for Injection, USP Sram per vial 19. If the veterinarian asked you to reconstitute the bottle to contain 165 mg/mL, how much sterile water would you add? MVS Bely Single-Ure VIA 20. What percent solution would this be?! 4. SANDOZ 21. If you were instructed to administer 363mg IV to the patient, how many mL would you draw up? 22. If you were instructed to administer the cefazolin by syringe pump over 20 minutes at a rate of 0.5 mL/minute, how much additional sterile water would add?

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Answer 1

ANSWERS 8.1 This unreconstituted bottle contains 1 gram of CEFAZOLIN Q. 19 → As the bottle contains Igram (1000mg) of lefazolin. We need to reconstitute it to 1.65 mg/ml, so we need to dilute it in 6.06 ml of sterite water. As, I gram of Cefazolin = looong. lng=11 hooo gm 165 mq = 165 gm We need 165mg/ml solution of cefazolin so we need - I litie = lovom so the solution would be lovo = 16.66ml, 165 so we require 6. 06 ml of Skerike water to prepare a solution of 165 mg/ml V Q. 20 The Percentage of solution would be 15 lop 5 | 6.5+ 1

Q. 21 - lovomg of cefazolin contains 6.06 me of sterite water 1000mg 6.06 me Img 6.06 me \ רש sto so, 363 mg -> 6.06_x363 = 2.199 9.goms Answer. 9.22 We need to provide cefazolin @rate of 0.5 ml 1 minute for 20 minutes. So, the total solution we need is 0.5820 = 10 ml gnitially we have 6.ooms so the additional quantity we require is 10-6.06= 13.94ms | Answer.

Answers to the above questions are-

Ques 18 - 1 Gram of Cefazolin

Ques 19 - We would add 6.06 ml of sterile water to make the required solution.

Ques 20 - Percentage of solution would br 16.5%.

Ques 21 - For 363 mg we would draw up 2..20 ml of Solution.

Ques 22 - Additionally we would add 3.94 ml of Sterile Water.