Question

MEDICATION CALCULATION #15

Order: prochlorperazine 10 mg., PO, tid

Available: Compazine (Prochlorperazine Maleate Tablets, USP) 5 mg & Prochlorperazine Maleate Tablets, USP 10 mg.

a. Which brand name drug would you select? Why?

b. How many tablet(s) should you give per dose?

Please show your detailed calculation.

Answer 1

(a)

Brand Name: Compazine

Prochlorperazine is an anti-psychotic medicine in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Prochlorperazine oral (taken by mouth) is used to treat psychotic disorders such as schizophrenia. It is also used to treat anxiety, and to control severe nausea and vomiting.

(b)

Oral:
-Usual dose: 5 to 10 mg orally 3 to 4 times a day
-Maximum dose: 40 mg/day
Parenteral:
IM:
-Usual dosage: 5 to 10 mg IM, repeated every 3 to 4 hours as necessary.
-Maximum dose: 40 mg/day
IV:
-Usual dose: 2.5 to 10 mg slow IV injection or infusion at a rate not exceeding 5 mg/min
-Maximum dose: 10 mg (single dose); 40 mg/day
Rectal:
-Usual dose: 25 mg rectally 2 times a day
Adult Surgery (Severe Nausea and Vomiting):
Parenteral:
IM:
-Usual dose: 5 to 10 mg IM 1 to 2 hours before anesthesia OR to control acute symptoms during/after surgery, repeated once (in 30 minutes) if necessary
-Maximum dose: 40 mg/day
IV:
-Usual dose: 5 to 10 mg slow IV injection or infusion (at a rate not exceeding 5 mg/min) 15 to 30 minutes before anesthesia OR to control acute symptoms during/after surgery, repeated once if necessary
-Maximum dose: 10 mg (single dose)

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