oteins: Solid-phase synthesis V 13 of 17 > The two structures below are the functionalized solid-phase...
1st attempt Which process in solid-phase peptide synthesis is being depicted in Step 2 of the figure below? AAZ HH NCC Resin Nc DCC AAZ DCC Fmoc AA1 0 H H.N-C- Fmoc-Red DCC - Resin AA2 AA1 Repeat 18 times Fmoc-N- Fmoc AA20 АА HAN 2 E ct P20 ct & c- Resin 18 P1 Repeat 18 times Fmoc AA20 АМ CIN Iu- 10- Resin AA Amino AA2 Amino P acid 1 cd2 Protecting group 1 po Protecting o group...
2. The structure of the solid phase Wang resin linker and the first amino acid that we will use in this lab is shown below Fmoc first amino acid linker a) (1 pt) If the resin has 0.72 mmol/g of this linker on the surface of the beads, and you use 300 mg of resin for the reaction, how many mmol of linker do you have? b) (3 pts) All peptides will use alanine at the C-tenminus (position 1), Fmoc-L-valine...
6. (a) Suggest structures for T, U, V, and in the reaction scheme below. 1. H. 10% Pd/C CHCI MOH th 2. Me 1 (H-Ala-OM) HN CO Me HATU, DIPEA DMF, rt, 16 h 1. Et,NH, CH.Clit, 2. FmocHNO.H (Fmoc-Gly-OH OBn HATU, DIPEA DMF, 1, 16 h U 1. PhSiH. cat. PdIPPhal CH.Cl2 tsh 2. HATU, DIPEA, DMF FmocHN - W O NHBO CH Phe-OM) HN CO Me rt, 16 h 1. TFA, CH.Cart 2 Me Me Fmoc-LOUCH FmocHN COH...