Question

CASE 1 John, a 63-year-old-man, noticed visible jaundice, which appeared to be deepening in color. He reported no history of pain, fever, or drug use, but he complained of weight loss and pale stools for the last few days. He was a moderate drinker. John had not experienced any previous episodes. Chemistry results: Total serum bilirubin: 20 mg/dL AST: 80 U/L ALT: 90 U/L ALP: 450 U/L 1. What is the likely diagnosis: hepatic or obstructive jaundice? What conditions are associated with this diagnosis? 2. Explain how you came to this decision. CASE 2 Mary, a five-year-old girl, had been seen previously for a fracture of the right foot. Her physician ordered a chemistry profile, which yielded an ALP of 840 U/L and a GGT of 30 U/L. There was no history of fever or any other medical illness. After the blood was centrifuged, the serum was visibly hemolyzed owing to difficulty obtaining the sample. Physical examination was unremarkable. nadults

Answer 1

And -1 hepatitis

because due to moderate drinking for several years can lead to the hepatitis formation and evaluation of AST,ALT,ALP

assosiated condition-

jaundice

portal hypertention

oesophagial Verice

how- as per moderatedrinking for several years lead to the fatty lever and then hepatitis

due to hepatitis there is portal vein obstruction and portal hypertension occurred

due to portal hypertension there is oesophageal vertices

case-2

1- as there bone are still growing so that they have heigher ALP ,person who recovering from bone injury also have heigher ALP

2- Due to haemolyzed rbc lead to elevation in ALP as they secrete ALP when get haemolyzed and also effect lab reports

3- Bone injury is most likely cause elevated ALP