Question

Q2. Both prednisolone (a corticosteroid) and ibuprofen (a non-steroid anti-inflammatory drug (NSAID) are associated with decreased eicosanoid (e.g. prostaglandins) production. Explain how this is achieved for each drug, noting any similarities and differences in the mechanism of action. (3 marks)

Answer 1

Ans.) Prednisolone is a corticosteroid made by the adrenal gland. It stimulates the synthesis of enzymes which are required to reduce the inflammatory response. It curbs the immune system by affecting the activity and capacity of the entire lymphatic system. It is used in the treatment of   arthritis, immune system disorders, breathing problems, cancer and severe allergies. It decreases immune system's response during several diseases which eventually reduces symptoms such as pain, swelling and allergic-type reactions.

Ibuprofen is a common pain reliever and generally used to treat headache, dental pain, menstrual cramps, muscle aches, or arthritis. It is a non-steroidal anti-inflammatory drug (NSAID). Essentially, it blocks the production of some natural substances in body that which are responsible for inflammation. It obstruct enzymes that are involved in prostaglandins production, resulting in low level of prostaglandins. As a result, inflammation, pain and fever are reduced by consumption of it.