Discuss the triple-therapy approach in the management of peptic ulcers and state reasons why some drugs...

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Discuss the triple-therapy approach in the management of peptic ulcers and state reasons why some drugs...

Discuss the triple-therapy approach in the management of peptic ulcers and state reasons why some drugs like NSAIDs need to be taken only after meals.

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Answer 1

Answer #1

Most people with peptic ulcers will be tested to see if they are infected with H. pylori.

Single antibiotic is not effective against H. pylori, hence combination therapy is given. The first-choice treatment for eradicating H. pylori is called triple therapy, and it includes:

a proton pump inhibitor and two antibiotics which are clarithromycin and amoxicillin.

These medicines need to be taken as prescribed by the doctor usually twice daily for 7 days.

Convenient ‘combination packs’ containing all the medicines for the treatment are available

It is important that we follow the treatment exactly according to our doctor’s prescription. The success rate is much lower if the tablets are not taken as directed.

Side effects often associated with triple therapy are nausea, diarrhoea and taste disturbance. Side effects are usually mild.

Drugs like NSAIDs need to be taken only after meals because

To reduce side effects of stomach irritation, including indigestion, stomach inflammation or ulcers drugs like NSAIDs need to be taken only after meals

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