Question

What role does the acetoxy group at the 3-position of cephalosporins have in enhancing antibacterial activity?

It acts as a good leaving group when the b-lactam ring is opened

It takes part in a transesterification reaction with the carboxylic acid group at position 4

It increases the reactivity of the b-lactam ring by neighbouring group participation

It acts as a steric shield and masks enzymatic attack at the b-lactam ring

Answer 1

The acefoxy group at 3.positon or Cephalosporins have in enhanching antibactenial activity : it acts as a good leaving group when the B-lactam ring is opened. ind. option. I is correct because opening or the Baractam ring or cephalosporing may coincide with a Concented mechanism that makes the expulsion or the acetoxy moiery as an acetate. Please give my Answer a thumbs up" Scanned with CamScanner