Question

Question Not yet answered Points out of 1.0 Which statement best describes the phase I reactions of drug metabolism? Select one: a. Phase I reactions are required for all drugs before they can undergo Phase II reactions b. Phase I reactions are due to enzymes which are primarily located in the kidney c. Phase I reactions involve the addition or unmasking of an-OH or other small polar group d. Phase I reactions involve both cytochrome P450 reductase and cytochrome P450 Flag question e.Phase I reactions occur in the rough endoplasmic reticulum f. All answers in this question are correct

Answer 1

f) All answers in this question are correct

Phase I reactions are required for all drugs before they undergo phase II reaction because it is the 1st step in drug metabolism.

Phase I reactions are due to enzymes which are primarily located in the kidney.

Phase I reaction include addition or unmasking of an -OH or other small polar group. In the phase I reaction the C and O oxdation, dealkalylation and N,S,P Oxidation, hydrolyse of epoxides, introduction of new hudrophilic functional groups to compounds are there.

Phase I reaction involve both cytochrome P450 and reductase and cytochrome P450 .   

Phase I reaction occur in rough endoplasmic reticulum specifically the oxidation and all occur in hepatic endoplasmic reticulum.