Detection of Sickle-Cell Disease by Gel Electrophoresis Firee samples of hemoglobin have been subjected to protein...
Sickle-cell Anemia Study Sickle-cell anemia or Sickle-cell disease, is a hereditary disorder. characterized by aryabnormality in the oxygen-carrying hemoglobin molecule in erythrocytes. Sickle-cell conditions have an autosomal recessive pattern of inheritance from parents. The sickle cell defect is a mutation of a single nucleotide of the hemoglobin B gene, which results in glutamic acid being substituted by a different amino acid at position 6. Hemoglobin with this mutation is referred to as Hbs, as opposed to the normal hemoglobin HbA....
1.Hemoglobin is a complex protein that contains four polypeptide chains. The normal hemoglobin found in adults –called adult hemoglobin –consists of two alpha and two beta polypeptide chains, which are encoded by different loci. Sickle-cell hemoglobin, which causes sickle-cell anemia, arises from a mutation in the beta chain of adult hemoglobin. Adult hemoglobin and sickle-cell hemoglobindiffer in a single amino acid: the sixth amino acid from one end in adult hemoglobin is glutamic acid, whereas sickle-cell hemoglobin has valine at...
(3) Polymorphism analysis of the sickle cell gene fragment (317 bp) that helps to make hemoglobin. A lab technician is conducting the polymorphism analysis of the sickle cell gene fragment (317 bp) using PCR and restriction digestion by Taq 1 on six individuals. A) Schematic representation of restriction sites of Taq l in the normal gene fragment. Two normal S1 and S2 restriction sites produce DNA fragments of 174, 78, and 65 bp. The sickle cell mutation removes the S2...
QUESTION 60 0.33334 points (E "Sickle cell anemia is produced by a genetic defect in the amino acid sequence of hemoglobin. Persons who are homozygous for this allele have abnormal red blood cells, which characterize the disease. The blood cells of heterozygous persons appear normal and they are considered carriers. A test reveals that a man is heterozygous for the sickle cell allele but his wife is homozygous normal. What is the probability of their children will be carriers of...
Protein molecules in solution can be separated from each other by taking advantage of their net charges. In the electric field between two electrodes, a positively charged particle moves toward the negative electrode and a negatively charged particle moves toward the positive electrode. This movement, known as electrophoresis, varies with the strength of the electric field, the charge of the particle, the size and shape of the particle, and the buffer/polymer gel combination through which the protein is moving. The...
Question 2 Imagine you are a scientist who intends to cure sickle cell disease. Which approach would be best suited to this goal? a. Dietary supplements to make up for an enzyme deficiency b. Modification of ribosomes to enhance translation c. Exposure to X-rays to induce a new mutation d. Dietary supplements to make up for an amino acid deficiency e. Editing the gene for a polypeptide component of hemoglobin Question 7 Stop codons terminate translation by a. increasing peptidyl...
My Study on Sickle Cell Anemia Research In 500 words, answer the following questions 1.Select your study sample 2. How have you selected your sample? 3. How will you select your sample population and give the rationale behind your decision Please type the solution on the keyboard so that I can copy and paste Q. No 1. Answer : Sickle cell disease : It is defined as it is a chronic heriditory form of Anemia, in which the red blood...
The following family tree contains many members who had or have the disease "Emseebeeitis" (indicated by the shaded circles and squares) (circles represent females and squares represent males). Those individuals who are healthy are indicated by unshaded figures. Those individuals who died have a slash mark. Those people who are still alive (1-16) were analyzed for a particular microsatellite "BH106". 1 2 3 DNA was isolated from each surviving member and microsatellite "BH106" was amplified by PCR and products were...
DNA DNA Replication: ONA Because DNA Is the ge m Tumes and heart e ine in process called DNA curs in the nucleus of s acest FS Parent strand Parent strand Newly replicated DNA Newly replicated DNA- SA0 Daughter DNA molecule Daughter DNA molecule Figure 8.2: Overview of DNA replication and illustration of complementary base pairing. DNA must replicate before cell division so that each new daughter cell receives an exact copy of the parent DNA. 1. Replication begins when...
can u tell me if these answers are correct please!??!!! Choose the best answer for the following questions. Place your answer on the line. If your answer is not on the line.it does not count 1 Mender's discovery that characteristics are inherited due to the transmission of hereditary factors resulted from his (1) dissections to determine how fertilization occurs in pea plants (2analysis of the offspring produced from many pea plant crosses (3) careful microscopic examinations of genes and chromosomes...