What ketone would you isolate after treatment of [a] with NaOEt and allyl bromide, followed by saponification and decarboxylation? (d) Give the structure of the mixed Claisen condensation product of ethyl phenylacetate and ethyl benzoate. Provide a mechanism for the following reaction.
What volume of 25% v/v allyl bromide solution is needed to
deliver the amount calculated in the table?
3-nitrobenzoic acid Allyl bromide Potassium carbonate Product Molar mass 120.98 207.18 167.12 N/A 138.21 N/A Boiling point 169-170 °C 71.3 °C N/A Melting point N/A 20.5 °C 142 °C N/A Density N/A 1.398 g/mL 1.238+0.06 g/mL Solid Liquid Solid Liquid State of matter at room temperature Molar equivalents 2.0 0.700 Starting mass or theoretical yield 0.807 Starting moles or theoretical yield 0.00483...
Question Two We change the substrate to allyl bromide and things change quite significant what are the products, and what mechanisms operate? H2O Hoo H - H₃ C CH3
Conditions Starting Material Major Product(s) OH PBrg Et20 NaCN DMF OMs NaNH2 DMSO, 20'C 8 hr 1) NaH, DMF, -78°C 2) A ci NaOH Br OH
Practice Problem 12.38 Propose a mechanism for the following reaction: BrMV он OH Nah 12.38a1 Draw step 1 of the mechanism using curved arrows. Include lone pairs and charges in your answer. н Edit I
Starting Material Conditions OH PBr3 Eto C NaCN OMs DMF Br NaNH DMSO, 20°C 8 hr 1) NaH, DMF, -78°C 2) A ci NaOH
What is the mechanism behind this? (Especially
on the NaH part)
5. Please identify X and Y in the reaction sequence below. ལམ་པ་མ་ཕམ་པ། ༤ 1)HBr 1) HBr , Y 2) PPh3, then NaH
what products will the following reactions form?
F3C-S 1. Nal, Acetone 2. NaCN, DMF 1. Nal, Acetone 2. CH3CO2Na, CH3CO2H a. NaH, THF OH b. O=SHO
15. What is the closest numerical value of the equilibrium constant K for the acid-base equilibrium between acetic acid and ammonia (left hand side of the equilibrium) and ammonium acetate ions (on the right hand side of the equilibrium arrows)? Lot Mo — Lorik Kollo (sins] H + NH3 + NH3 K = = K= a) 100,000 b) 10 c) -10 d) -100,000 16. What are the best reagents and reaction conditions to accomplish the kinetic allylation of 2- methylcyclopentanone?...
1) R'-MgBr in THF 2)H,o NaH Ho or OH PAA X2. H20 1) Hg(OAc)2, R'OH 2) NaBH4, NaOH, H20 Os0 NaHSO, H2O I) 2)CH, SCH HyIO HBr ROOR 1)BH3. THF 2)H202, NaOH, H2O Mg, THF PBr3 NaOH )OTHF 2) H30 CrOj. H,SO, 1) NaH 2)RXDMF "О-R DMF PCC DCM ) THF 2) H3O+ SOCI pyridine Li Hexanes