Question

The hydrogen-potassium adenosine triphosphatase (H⁺/K⁺ATPase) is found at the surface of the certain gastric cells in the wall of the stomach. It exchanges potassium ions (K⁺) from the intestinal lumen with cytoplasmic protons (H⁺) which will eventually form hydrochloric acid (HCl) in the stomach, also known as gastric acid. Proton pump inhibitors are a group of drugs that can be used in the treatment of acid-reflux disorders and peptic ulcer disease. Rabeprazole is an example of a proton pump inhibitor. Rabeprazole inhibits the gastric H⁺/K⁺ATPase, decreasing the production of HCl in the stomach.

Drag and drop the components below into the correct configuration to visualize this pathway.

Drug Cellular protein Intestinal lumen Cytosol Rabeprazole H*/K* ATPase HCI

Answer 1

Pathway for mechanism of H⁺/K⁺ ATPase for formation of gastric juice, and inhibition of it by Rabeprazole is shown below :

Drug Rabeprazole K+ HCI Cl Cellular protein Intestinal lumen H+/к+ АTРase Cytosol K+ Н+ Rabeprazole H-/K ATPase НC н- K*