Patient #1 is a 35yo male who brought in a urine jug for a 24hr creatinine...
Patient #1 is a 35yo male who brought in a urine jug for a 24hr creatinine clearance. The volume of the urine was 1000mL. The patient’s height is 6ft and he weighs 230lbs, with an approximate body surface area of 2.24.
Creatinine Clearance Results:
Range Serum Creatinine: 0.8mg/dL (0.6-1.2) mg/dL
Urine Creatinine: 66.2mg/dL Clearance Rate: (85-125) mL/min
Determine the Clearance Rate.
- What is the discrepancy in these results?
- Name at least 3 possible reasons for this discrepancy:
Homework Answers
Creatinine, is released into serum as a byproduct of beakdown of muscle tissue.
This byproduct is filtered through kidney and then excreted through urine
Measurement of creatinine helps us to calculate the Glomerular Filtration Rate.
Creatinine clearance rate is the amount of blood that can be made free of creatinine every minute, hence reflects the blood flow through kidney
Normal: 95 milliliters per minute for women
120 milliliters per minute for men
Creatinine is released into serum as a byproduct of breakdown of muscle tissue.
This byproduct is filtered through kidney and then excreted through urine
Measurement of creatinine helps us to calculate the Glomerular Filtration Rate.
Creatinine clearance rate is the amount of blood that can be made free of creatinine every minute, hence reflects the blood flow through kidney
Normal: 95 milliliters per minute for women
120 milliliters per minute for men
Muscle mass increases the creatinine clearance rate. In this person if we claculate creatinine clearance using serum creatinine only the values will be very high (190 ml/min)
If we consider urine creatinine and his Body Surface Area along with Serum Creatinine his Creatinine Clearance will be 57.5ml/min and corrected will be 44 ml/min/1.73 m2. which means patient is in failure
Hence Height, Weight of the Patient must be considered while claculating Creatinine Clearance
Factors causing discrepancies are Age, Sex, Ethinicity, Muscle mass (Over weight/Underweight), Food Intake, Amount of Urine collected for the test
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