How can you tell if a reactant, like the NaOH, is a strong/weak nucleophile or base to determine what mechanism you use? The picture provided has the correct answers. I just don't understand how to get to them.
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How can you tell if a reactant, like the NaOH, is a
strong/weak nucleophile or base...
How can you tell what is a weak/strong nucleophile and a weak/strong base to determine what mechanism you use (SN1, SN2,...
How can you tell what is a weak/strong nucleophile and
a weak/strong base to determine what mechanism you use (SN1, SN2,
E1, E2)?
3. Draw a structural formula for the major organic product(s) of each reaction and specify the mechanism by which each product is formed (SNI, SN2, El, or E2). NaOH HO CH2CH ON CH3CH OH CHON CH,OH CH,OH DMSO
strong nucleophile weak base strong bulky base strong nucleophile strong base Promote SN2/E2 weak nucleophile weak...
strong nucleophile weak base strong bulky base strong nucleophile strong base Promote SN2/E2 weak nucleophile weak base Promote SN1/E1 Promote SN2 Promote E2 CH Br HS NCT HO CHO CHÚCHO NaNO NaOH NOME Noe HOORS Conjugate acids have pka 16-18 Conjugate acids Recall, you make hydroxide have pka 11 or alkoxide ons from the corresponding alcohol or water and Nat CH,OH (MOH) HO CH,CH,OH (EXOH) | HC-Ć-o to CH tert-BUOK NOCH KOHBU NEOBU The structures above are all ways of...
please explain why and how they are E2/SN2/SN1/E1 3. Draw a structural formula for the major organic product(s) of e...
please explain why and how they are E2/SN2/SN1/E1
3. Draw a structural formula for the major organic product(s) of each reaction and specify the mechanism by which each product is formed (SNI, S2, El, or E2). • NaOH H20 CH,CH ON CH,CH OH CH ON CH,OH CH OH Na DMSO
2. (1.5 pts) Label the following reagents as Good or Poor Nucleophiles AND as Strong or Weak Base...
2. (1.5 pts) Label the following reagents as Good or Poor Nucleophiles AND as Strong or Weak Bases. OK Na SH 3. (1.5 pt) Predict the productts) of the following reactions, if there are multiple products indicate which, if any, is the major product. Be sure to clearly mark the stereochemistry of chiral carbon atoms and draw multiple products if there is more than one stereoisomer that forms. HCI MeOH H2SO H2 Pd/BaSO4 quinoline 4. (3 pt) For the following...
3. Draw a structural formula for the major organic product(s) of each reaction and specify the...
3. Draw a structural formula for the major organic product(s) of each reaction and specify the mechanism by which each product is formed (Syl, SN2, E1, or E2). NaOH HO CH3CH2ON CH3CH2OH CH ON CH OH Br CH,OH Na DMSO
can someone please explain to me how to tell whether substitution (sn1/sn2) or Elimination (E1/E2) im...
can someone please explain to me how to tell whether substitution (sn1/sn2) or Elimination (E1/E2) im mostly confused on nucleophile or base strong or weak like is there a step by step that you know thats great for knowing what mechanisms to use ? please please be descriptive . write steps to finish mechanism. and explain nucleophile/base/strong/weak and what goes with what mech.
3. a. List the and state if( ) (10 pts ca.) i. Nucleophile (strong/weak), Basicity (strong/weak)...
3. a. List the and state if( ) (10 pts ca.) i. Nucleophile (strong/weak), Basicity (strong/weak) ii. Substrate (1°/2°/3°) iii. Leaving group (good/poor) iv. Solvent (protic/aprotic) b. Label the mechanism for the reaction (S1/S2/E1/E2) c. Draw the mechanism for the reactions and predict the major product(s). Use proper stereochemistry where necessary d. State which is the rate determining step (RDS) e. Give a rate law for each reaction. Ex: Rate=K[ A B NaSCH CH2CN OH HI MeOH
SN 2: Mechanism: Br NaOH E2: Mechanism: Br NaOH 20 30 Methyl 1° Strong Weak 30...
SN 2: Mechanism: Br NaOH E2: Mechanism: Br NaOH 20 30 Methyl 1° Strong Weak 30 Preferred Alkyl Halides: Preferred Nucleophiles: Product Stereochemistry: Methyl 1° Strong 2° Weak Preferred Alkyl Halides: Preferred Base: Reagent Stereochemistry: Product Regiochemistry: Sw1: Mechanism: ~ Br H2O E1: Mechanism: Br H2O Preferred Alkyl Halides: Methyl 1° 30 20 Preferred Alkyl Halides: Preferred Nucleophiles: Product Stereochemistry: Methyl 1° Strong 20 Weak Weak Strong Preferred Base: Product Regiochemistry:
please show all steps including each mechanism (arrows) and also if SN1 has any rearrangements of...
please show all steps including each mechanism (arrows) and
also if SN1 has any rearrangements of carbocation intermediate
through a hydride shift and/or methyl shift. DO NOT NEED
ELIMINATION. ONLY SUBSTITUTION.
Sy1/E1 versus S2/E2 Learning Checks Draw the major organic substitution and/or elimination products in the following reactions. If no reaction is possible, write “No Reaction". Substitution Product(s) Elimination Product(s) 2) 2) OH BrCH K* -Ot-Bu NaOCH н"Сн, сн,он нсн, Ph NaOCH Br H CH3OH CH NaOCH NaOH T.CH, I...
_1. An alkyl halide which might be expected to undergo rearrangement under Snl or E1 conditions...
_1. An alkyl halide which might be expected to undergo rearrangement under Snl or E1 conditions is: HZC Br CH3 A. 1 B. | F—CH,BH C. CH3-C-CH-CH, CHz CH3 D. CH3 CH3-C-CH2CH2-Br CH3 E. A Br 2. Your task is to convert 2-chloropentane into 1-pentene. Which reagents would you choose? a) NaOH/H20 b) KOH/CH3OH c) CH3ONa/CH3OH d) CH3CH2ONa/CH3CH2OH e) (CH3)3COK/(CH3)3COH 3. Circle the reaction below which is faster in polar protic solvents. OH,H,O A. CH,CH,CH,Br- CH,CH,CH,OH + Br or SH.RSH...
How can you tell what is a weak/strong nucleophile and
a weak/strong base to determine what mechanism you use (SN1, SN2,
E1, E2)?
3. Draw a structural formula for the major organic product(s) of each reaction and specify the mechanism by which each product is formed (SNI, SN2, El, or E2). NaOH HO CH2CH ON CH3CH OH CHON CH,OH CH,OH DMSO
strong nucleophile weak base strong bulky base strong nucleophile strong base Promote SN2/E2 weak nucleophile weak base Promote SN1/E1 Promote SN2 Promote E2 CH Br HS NCT HO CHO CHÚCHO NaNO NaOH NOME Noe HOORS Conjugate acids have pka 16-18 Conjugate acids Recall, you make hydroxide have pka 11 or alkoxide ons from the corresponding alcohol or water and Nat CH,OH (MOH) HO CH,CH,OH (EXOH) | HC-Ć-o to CH tert-BUOK NOCH KOHBU NEOBU The structures above are all ways of...
please explain why and how they are E2/SN2/SN1/E1
3. Draw a structural formula for the major organic product(s) of each reaction and specify the mechanism by which each product is formed (SNI, S2, El, or E2). • NaOH H20 CH,CH ON CH,CH OH CH ON CH,OH CH OH Na DMSO
2. (1.5 pts) Label the following reagents as Good or Poor Nucleophiles AND as Strong or Weak Bases. OK Na SH 3. (1.5 pt) Predict the productts) of the following reactions, if there are multiple products indicate which, if any, is the major product. Be sure to clearly mark the stereochemistry of chiral carbon atoms and draw multiple products if there is more than one stereoisomer that forms. HCI MeOH H2SO H2 Pd/BaSO4 quinoline 4. (3 pt) For the following...
3. Draw a structural formula for the major organic product(s) of each reaction and specify the mechanism by which each product is formed (Syl, SN2, E1, or E2). NaOH HO CH3CH2ON CH3CH2OH CH ON CH OH Br CH,OH Na DMSO
3. a. List the and state if( ) (10 pts ca.) i. Nucleophile (strong/weak), Basicity (strong/weak) ii. Substrate (1°/2°/3°) iii. Leaving group (good/poor) iv. Solvent (protic/aprotic) b. Label the mechanism for the reaction (S1/S2/E1/E2) c. Draw the mechanism for the reactions and predict the major product(s). Use proper stereochemistry where necessary d. State which is the rate determining step (RDS) e. Give a rate law for each reaction. Ex: Rate=K[ A B NaSCH CH2CN OH HI MeOH
SN 2: Mechanism: Br NaOH E2: Mechanism: Br NaOH 20 30 Methyl 1° Strong Weak 30 Preferred Alkyl Halides: Preferred Nucleophiles: Product Stereochemistry: Methyl 1° Strong 2° Weak Preferred Alkyl Halides: Preferred Base: Reagent Stereochemistry: Product Regiochemistry: Sw1: Mechanism: ~ Br H2O E1: Mechanism: Br H2O Preferred Alkyl Halides: Methyl 1° 30 20 Preferred Alkyl Halides: Preferred Nucleophiles: Product Stereochemistry: Methyl 1° Strong 20 Weak Weak Strong Preferred Base: Product Regiochemistry:
please show all steps including each mechanism (arrows) and
also if SN1 has any rearrangements of carbocation intermediate
through a hydride shift and/or methyl shift. DO NOT NEED
ELIMINATION. ONLY SUBSTITUTION.
Sy1/E1 versus S2/E2 Learning Checks Draw the major organic substitution and/or elimination products in the following reactions. If no reaction is possible, write “No Reaction". Substitution Product(s) Elimination Product(s) 2) 2) OH BrCH K* -Ot-Bu NaOCH н"Сн, сн,он нсн, Ph NaOCH Br H CH3OH CH NaOCH NaOH T.CH, I...
_1. An alkyl halide which might be expected to undergo rearrangement under Snl or E1 conditions is: HZC Br CH3 A. 1 B. | F—CH,BH C. CH3-C-CH-CH, CHz CH3 D. CH3 CH3-C-CH2CH2-Br CH3 E. A Br 2. Your task is to convert 2-chloropentane into 1-pentene. Which reagents would you choose? a) NaOH/H20 b) KOH/CH3OH c) CH3ONa/CH3OH d) CH3CH2ONa/CH3CH2OH e) (CH3)3COK/(CH3)3COH 3. Circle the reaction below which is faster in polar protic solvents. OH,H,O A. CH,CH,CH,Br- CH,CH,CH,OH + Br or SH.RSH...
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