1. Calculate the daily maintenance dose of a drug A if CI is 146.7 L/day, Css...
Levodopa, a drug used in the treatment of Parkinson’s disease, has a small initial dose followed by a steady increase over several days. Suppose a patient is given three doses a day. Each administration is 250 mg on the first day, and is increased by 250 mg every fourth day. The maintenance dose is reached after 28 days. Calculate the initial and final daily doses of levodopa administered to the patient.
A 12-kg dog is receiving maintenance fluids at a rate of 50 mL/kg/day (24 hours). A drug with the strength of 1.8 mg/mL and a dose rate of 2 mg/kg is to be added to a 1-L bag of fluid. What volume of the drug is to be added?
Mrs. Robinson is 75-years-old and weighs 110 kg. You attempt to determine the optimal maintenance dose. Your target serum concentration is 54.7 ug/ml, bioavailability is 0.86, CL = 19 ml/H/kg, and Vd = 1.6 L/kg. The standard dosing interval for this drug is 12 hours.
A maintenance dose of amantadine is 200 mg/day, given in two administrations. If amantadine is given to a patient as a syrup, which has a concentration of 10 mg/ml, for how many days will a 480-ml bottle of drug last?
1. Calculate the total volume of drug that would be given in one dose for this order: Zofran 16 mg PO BID Available: Zofran oral solution labelled 4 mg per 5 mL 2. How many tablets will be required for one day to administer this order: Raloxifene HCl 120 mg PO BID. The drug is available as Raloxifene 60 mg per tablet. (2 marks)
Order: tobramycin (Nebcin) 10mg IM Q8hr. Child weighs: 10kg Safe drug dose range: 3mg/kg/day Available: 20mg/2mL 1. 2. 3. Determine the daily safe dose range for the child: How many mL should the child receive per dose: Is it safe to give? Yes or No
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
1. A new drug was given in a single intravenous dose of 200 mg to an 80- kg adult male patient. The apparent VD is 0.8 L/kg, and the drug is eliminated by 1st order kinetics. Compute the initial drug plasma concentration. 2. A drug has an elimination half-life of 4 hours and follows first-order kinetics. If a single 600-mg dose is given to a patient by IV bolus, what percent of the dose is lost in 12 hours?
Calculate the daily rate of maintenance fluids and the IV hourly flow rate for a child who weighs 25 kg. A) 130 mL per day, 5.4 mL/h B) 260 mL per day, 10.8 mL/h C)1,150 mL per day, 47.9 mL/h D) 650 mL per day, 27 mL/h
Calculate the daily rate of maintenance fluids and the IV hourly flow rate for a child who weighs 44 pounds. O A. 1,100 mL/day, 46 mL/hr O B. 850 mL/day; 35 m/hr O c. 1,500 mL/day; 62 mL/hr 0 D. 1,200 mL/day: 50 mUhr