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you know that Na/k pumps are a form of active cross-membrane transport of Na and K...

you know that Na/k pumps are a form of active cross-membrane transport of Na and K ions, which means, it takes energy for these pumps to work. imagine a situation, where blood flow through a part of the brain gets interrupted due to a blood clot. this part of the brain now does not get blood perfusion, and therefore it gets no oxygen and energy fuel in order to keep the Na/K pumps going in those brain cells. Very soon, these brain cells swell up with water and die. Explain, how and why the cells swell up (or even burst) if their Na/K pumps stop working.

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Answer #1

When the blood flow through the parts of the brain get interrupted due to a blood clot, there will be decreased in oxygen and energy to maintain the Na / K pumps to function inside the cell. This will leads to deposition of Na ions inside the cells.
The primary work of the Na / K pump is to relive the Na ions out of the cells and get the K ions into the cells. when the Na gets move out of the cells the water which is present inside the cell will follow and get out from the cells.

But when this Pump get failed, the Na will deposited inside the cells, Generally Water loves to stay with the Na ions. So Every Cells in the region get accumulated and swollen due to Water molecules and in some case it will burst out.

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