Reflection for the following article "Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1"
Ans)
Novel human coronavirus which is presently called as acute respiratory syndrome Coronavirus 2,shortly called as SARS- CoV-2, which firstly appeared in china in the year 2019.Now it is examined that the aerosol and surface stability of the SARS-CoV-2 and contrasted that with the SARS-CoV-1,intimately associated human Coronavirus.
The strength of the SARS-CoV-2 and the SARS- Cov-1 in the aerosols and on several surfaces are assessed and evaluated its decay scale with the help of a Bayesian regression model.The strains which are utilized are CoV-2 nCoV-WA1-2020 and SARS-CoV-1 Tor2 .
Aerosols consisting SARS-CoV-1 or the SARS-CoV-1 are reated with the utilization of 3- jet collision nebulizer and which is provided to a Goldberg cylinder to produce an aerosolized surrounding.Inoculum followed the cycle-threshold range in the middle of 20 and 22, identical to those noticed in samples acquired from superior and inferior respiratory area in human beings.
The SARS-CoV stayed feasible in the aerosols all through the period of examination,with decrement in the infectious titer and this decrement was identical to which noticed with the SARS-CoV-1.
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Reflection for the following article "Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1"
What is the structure and origin of SARS-CoV-2 virus? What are its symptoms? Compare diseases caused by SARS-CoV-1, SARS-CoV-2, and MERS-CoV. Why do you think an effective vaccine can be available only in 1 -1.5-2 years? What treatment for COVID-19 do you know?
1-1. The SARS-CoV-2 is an enveloped virus, meaning it is surrounded by a bilayer of membrane that it acquires as it exits the host cell. a. What is the host membrane bilayer made of? b. What is the other main macromolecule that comprises the “fluid mosaic” model of a cell membrane? 1-2. To gain entry, spikes of the SARS-CoV-2 bind to angiotensin-converting enzyme 2 (ACE2) found in epithelial cells especially of the respiratory and oral passageways. As such, these cells...
List basic structural characteristics of SARS-CoV-2
Q4. The SARS-CoV-2 virus responsible for the global COVID-19 outbreak is known to persist on many surfaces. On a stainless steel surface, it has been shown to have an active half of around 5.6 hours, presumably having a first order type of degradation. (a). How long would a contaminated stainless steel surface take to fall below a level of 1% of the initial contamination? (b). Precisely what is a safe level of exposure to SARS-CoV-2 remains unknown and may be...
Find SARS-CoV-2 on the phylogeny above – this is the virus that causes COVID-19. There have been two previous major coronavirus outbreaks in 21st century – SARS in 2002-2003 (caused by the virus SARS-CoV) and MERS in 2012-2013 (caused by the virus MERS-CoV). (a)Based on the phylogeny above, how do we know that COVID-19 is a new disease and not a resurgence of SARS or MERS? Be specific and refer to the relationships shown on the phylogeny in your answer....
what have you learned personally from researching SARS-CoV-2
1.In early March, it was reported that two main strains of SARS-CoV-2 had been identified, termed S and L, with the S type being the less virulent ancestral form representing about 30% of prevalence and the more virulent L type having descended from the S type and representing about 70% of prevalence. However, the prevalence of the more virulent L type seems to have decreased after early January, and it is thought that this resulted from human intervention against this...
How could the specific proteins (S, E, M, and N) on SARS-CoV-2 be useful targets for diagnosis? (1) For treatment? (1) What technologies or molecular diagnostics/therapeutics would be useful? (1)
Explain the importance of evolution in the recent appearance of SARS-CoV-2. Your answer should demonstrate that you understand the concept of evolution and related concepts covered in the course.
5.To gain entry, spikes of the SARS-CoV-2 bind to angiotensin-converting enzyme 2 (ACE2) found in epithelial cells especially of the respiratory and oral passageways. As such, these cells are susceptible to infection by SARS-CoV-2. ACE2 is a protein consisting of multiple alpha-helices that is embedded in, and spans, the membrane. What is this type of protein called, and what structure do the alpha helices represent? 6.Following binding of spike proteins to ACE2, SARS-CoV-2 likely gains entry into the cell either...