List basic structural characteristics of SARS-CoV-2
Lipid membrane (enveloped virus) encloses the proteinaceous capsid.
The capsid contains nucleoprotein or genetic material (RNA).
Lipid membrane consists of hemagglutinin esterase enzyme and membrane protein.
The membrane is covered by spikes made up of proteins.
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Reflection for the following article "Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1"
What is the structure and origin of SARS-CoV-2 virus? What are its symptoms? Compare diseases caused by SARS-CoV-1, SARS-CoV-2, and MERS-CoV. Why do you think an effective vaccine can be available only in 1 -1.5-2 years? What treatment for COVID-19 do you know?
Find SARS-CoV-2 on the phylogeny above – this is the virus that
causes COVID-19. There have been two previous major coronavirus
outbreaks in 21st century – SARS in 2002-2003 (caused by the virus
SARS-CoV) and MERS in 2012-2013 (caused by the virus MERS-CoV).
(a)Based on the phylogeny above, how do we know that COVID-19 is
a new disease and not a resurgence of SARS or MERS? Be specific and
refer to the relationships shown on the phylogeny in your
answer....
what have you learned personally from researching SARS-CoV-2
5.To gain entry, spikes of the SARS-CoV-2 bind to
angiotensin-converting enzyme 2 (ACE2) found in epithelial cells
especially of the respiratory and oral passageways. As such, these
cells are susceptible to infection by SARS-CoV-2. ACE2 is a protein
consisting of multiple alpha-helices that is embedded in, and
spans, the membrane. What is this type of protein called, and what
structure do the alpha helices represent?
6.Following binding of spike proteins to ACE2, SARS-CoV-2 likely
gains entry into the cell either...
1-1. The SARS-CoV-2 is an enveloped virus, meaning it is surrounded by a bilayer of membrane that it acquires as it exits the host cell. a. What is the host membrane bilayer made of? b. What is the other main macromolecule that comprises the “fluid mosaic” model of a cell membrane? 1-2. To gain entry, spikes of the SARS-CoV-2 bind to angiotensin-converting enzyme 2 (ACE2) found in epithelial cells especially of the respiratory and oral passageways. As such, these cells...
Explain the importance of evolution in the recent appearance of SARS-CoV-2. Your answer should demonstrate that you understand the concept of evolution and related concepts covered in the course.
How could the specific proteins (S, E, M, and N) on SARS-CoV-2 be useful targets for diagnosis? (1) For treatment? (1) What technologies or molecular diagnostics/therapeutics would be useful? (1)
The current tests for SARS-CoV-2 virus rely on a type of PCR used specifically for RNA samples called “Reverse Transcriptase Polymerase Chain Reaction”. Explain the process of PCR and how it is used help determine if some has COVID-19.
Q4. The SARS-CoV-2 virus responsible for the global COVID-19 outbreak is known to persist on many surfaces. On a stainless steel surface, it has been shown to have an active half of around 5.6 hours, presumably having a first order type of degradation. (a). How long would a contaminated stainless steel surface take to fall below a level of 1% of the initial contamination? (b). Precisely what is a safe level of exposure to SARS-CoV-2 remains unknown and may be...