Question

Explain the reasons why certain medications are better analyzed using (Conductometric titration) and other better analyzed using (Potentiometric titration ) of these methods more than the other?????

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Answer 1

Ans) Conductometric titration is a type of titration in which the electrolytic conductivity of the reaction mixture is continuously monitored as one reactant is added. The equivalence point is the point at which the conductivity undergoes a sudden change.

Eg. Conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as the titrant. The method was based on the formation of insoluble silver chloride (AgCl) by the reaction of the chloride ion associated with propranolol hydrochloride molecule the silver ions of the titrant. The effect of the propranolol hydrochloride/AgNO3 concentrations and the interval of time between the successive additions of the titrant on the shape of the titration curve were studied. The obtained recoveries for four samples ranged from 96.8% to 105%.

- Potentiometric titration is a volumetric method in which the potential between two electrodes is measured (referent and indicator electrode) as a function of the added reagent volume.

The part of the curve that has the maximum change marks the equivalence point of the titration.

- Potentiometric titrations involves the measurement of the potential of a suitable indicator electrode with respect to a reference electrode as a function of titrant volume.