2.NSAIDs work by inhibiting which enzyme? A. Peroxidase B. Lipoxygenase C. Cyclooxygenase D. Phospholipase
2.NSAIDs work by inhibiting which enzyme? A. Peroxidase B. Lipoxygenase C. Cyclooxygenase D. Phospholipase
Homework Answers
Option C is correct
Because NSAIDs the non steroidal anti-inflammatory medication inhibit the enzyme Cyclooxygenas (COx 1 & Cox 2), it is the enzyme responsible for production of various inflammatory mediators specially PGs (Prostaglandins) , which cause pain inflammation and fever.
Hence paracetamol, ibuprofen, celecoxib and rofecoxib etc inhibit the Cyclooxygenase enzyme in selective and non selective manner.
Add Answer to:
2.NSAIDs work by inhibiting which enzyme? A. Peroxidase B.
Lipoxygenase C. Cyclooxygenase D. Phospholipase
40. How can inhibiting the activation of phospholipase A2 impact eicosanoid biosynthesis? Release of arachidonic acid...
40. How can inhibiting the activation of phospholipase A2 impact eicosanoid biosynthesis? Release of arachidonic acid by phospholipase A2 is the first step in the pathway b. Drugs that inhibit phospholipase A2 stimulate the synthesis of eicosanoids c. Inhibiting phospholipase A2 could favor the synthesis of prostaglandins d. Inhibitors of phospholipase A2 can only block the synthesis of leukotriene's
Exercise 1: Comparison of NSAIDs Data Table 1. Comparison of Common NSAIDs. Generic name Commercial brand...
Exercise 1: Comparison of NSAIDs Data Table 1. Comparison of Common NSAIDs. Generic name Commercial brand name(s) Prescription only Typical uses Enzymes inhibited Source(s) Meloxicam Mobic x Reduce pain and swelling associated with osteoarthritis and rheumatoid arthritis COX-1 & COX 2 Indicate your resources here Aspirin Naproxen Ibuprofen Celecoxib Diclofenac Questions Define the acronym NSAID. Why are NSAIDs valuable to medicine? What property of aspirin makes it unique among the NSAIDs? Define the roles of the cyclooxygenase enzyme and prostaglandins...
12. Which of the following has a carbohydrate as part of its structure? A. Platelet activating...
12. Which of the following has a carbohydrate as part of its structure? A. Platelet activating factor B. Ganglioside C. Sphingosine D. Ceramide E. Diacylglycerol 13. Celebrex targets specifically: A. Cyclooxygenase-1 B. Thromboxane Synthase C. Lipoxygenase D. Cyclooxygenase-2 E. Phospholipase A2 22. The human genetic disease phenylketonuria (PKU) can result from: A. Deficiency of protein in the diet B. Inability to catabolize ketone bodies C. Inability to synthesize tetrahydrobiopterin D. Inability to synthesize phenylalanine E. Production of enzymes that catabolize...
(Only answer 'B'). The more specific you are, the better! Phospholipase A2 is an enzyme that...
(Only answer 'B'). The more specific you are, the better!
Phospholipase A2 is an enzyme that cleaves the ester linkage on C-2 of glycerol of phospholipids. It has a variety of purposes in the cell, many of which are outlined in your book. Additionally, the venoms of several dangerous creatures also contain enzymes with phospholipase A2 activity. The eastern diamondback rattler and Indian cobra, for instance, kill more than 10% of their human victims. The breakdown product of phospholipids is...
103. Which of the following neurotransmitters may be required in the diet of a patient who...
103. Which of the following neurotransmitters may be required in the diet of a patient who has a deficiency of tetrathydrobiopterin (THB)? A. 5-hydroxytryptophan B. Histamine C. gamma-amino butyric acid (GABA) D. Dopamine E. Both A and D 106. What vitamin is a precursor to coenzyme A? A. Niacin B. Thiamine C. Riboflavin D. Pantothenic Acid E. Pyridoxine 107. Which enzyme is believed to be the target for acetaminophen? A. Cyclooxygenase-1 B. Cyclooxygenase-3 C. Lipooxygenase D. Cyclooxygenase-2 E. Phospholipase A2...
3. Many snake venoms contain a phospholipase A2 enzyme that hydrolyzes the C2 fatty acid from...
3. Many snake venoms contain a phospholipase A2 enzyme that hydrolyzes the C2 fatty acid from a phospholipid to yield a corresponding lysophospholipid with a single hydrocarbon tail. High concentrations of lysophospholipids can disrupt membrane function and lead to cell death. 0 0 CH-0-0-R R-0-0-CH 0 CH2-0-P-0-X 0 Phospholipid HOR -C-OH free fatty acid CH-0-C-R + H-0ẠCH 0 phospholipase A2 CH,-0-2--0-X 0 Lysophospholipid Figure 2. Action of phospholipase A2. X=polar head group. R=long hydrocarbon tails. a. Phospholipids do not form...
The enzyme Phosphokinase C (PKC) is activated via a signaling cascade that begins with the action...
The enzyme Phosphokinase C (PKC) is activated via a signaling cascade that begins with the action of the enzyme Phospholipase C in a cell membrane. The following chemical entities are involved in this cascade: i) Ca2+ ii) IP3 iii) Diacylglycerol Which of these is/are directly involved in binding to PKC? A. i) B. ii) C. iii) D. i) and iii) E. ii) and iii)
The venom of the Eastern diamondback rattler and the Indian cobra contains phospholipase A2, which catalyzes...
The venom of the Eastern diamondback rattler and the Indian cobra contains phospholipase A2, which catalyzes the hydrolysis of fatty acids at the C-2 position of glycerophospholipids. The phospholipid breakdown product of this reaction is lysolecithin (lecithin is phosphatidylcholine). At high concentrations, lysophospholipids act as detergents, dissolving the membranes of erythrocytes and lysing the cells. Extensive hemolysis may be life-threatening. Draw the lysolecithin that results when a phosphatidylcholine molecule is exposed to phospholipase A2. Represent any acyl groups as "R."...
2 H 20? Which enzyme catalyzes the reaction: H202 + 2H Peroxidase Superoxide dismutase Catalase Oxidase...
2 H 20? Which enzyme catalyzes the reaction: H202 + 2H Peroxidase Superoxide dismutase Catalase Oxidase QUESTION 2 Which of the following is the best definition of fermentation? The production of ethanol from glucose The production of energy by substrate level phosphorylation The reduction of glucose to pyruvic acid The complete catabolism of glucose to CO2 and H2O The oxidation of glucose with organic molecules serving as electron acceptors QUESTION 3 The best definition of osmotic pressure is The active...
Which of the following would result from the action of phospholipase C on a membrane glycerophospholipid? A. Glycer...
Which of the following would result from the action of phospholipase C on a membrane glycerophospholipid? A. Glycerol and two fatty acids B. One fatty acid and one monoacylglycerol C. A sugar phosphate and glycerol D. A lysophospholipid and a diacylglycerol E. A diacylglycerol and a polar group containing phosphate
40. How can inhibiting the activation of phospholipase A2 impact eicosanoid biosynthesis? Release of arachidonic acid by phospholipase A2 is the first step in the pathway b. Drugs that inhibit phospholipase A2 stimulate the synthesis of eicosanoids c. Inhibiting phospholipase A2 could favor the synthesis of prostaglandins d. Inhibitors of phospholipase A2 can only block the synthesis of leukotriene's
(Only answer 'B'). The more specific you are, the better!
Phospholipase A2 is an enzyme that cleaves the ester linkage on C-2 of glycerol of phospholipids. It has a variety of purposes in the cell, many of which are outlined in your book. Additionally, the venoms of several dangerous creatures also contain enzymes with phospholipase A2 activity. The eastern diamondback rattler and Indian cobra, for instance, kill more than 10% of their human victims. The breakdown product of phospholipids is...
3. Many snake venoms contain a phospholipase A2 enzyme that hydrolyzes the C2 fatty acid from a phospholipid to yield a corresponding lysophospholipid with a single hydrocarbon tail. High concentrations of lysophospholipids can disrupt membrane function and lead to cell death. 0 0 CH-0-0-R R-0-0-CH 0 CH2-0-P-0-X 0 Phospholipid HOR -C-OH free fatty acid CH-0-C-R + H-0ẠCH 0 phospholipase A2 CH,-0-2--0-X 0 Lysophospholipid Figure 2. Action of phospholipase A2. X=polar head group. R=long hydrocarbon tails. a. Phospholipids do not form...
The venom of the Eastern diamondback rattler and the Indian cobra contains phospholipase A2, which catalyzes the hydrolysis of fatty acids at the C-2 position of glycerophospholipids. The phospholipid breakdown product of this reaction is lysolecithin (lecithin is phosphatidylcholine). At high concentrations, lysophospholipids act as detergents, dissolving the membranes of erythrocytes and lysing the cells. Extensive hemolysis may be life-threatening. Draw the lysolecithin that results when a phosphatidylcholine molecule is exposed to phospholipase A2. Represent any acyl groups as "R."...
2 H 20? Which enzyme catalyzes the reaction: H202 + 2H Peroxidase Superoxide dismutase Catalase Oxidase QUESTION 2 Which of the following is the best definition of fermentation? The production of ethanol from glucose The production of energy by substrate level phosphorylation The reduction of glucose to pyruvic acid The complete catabolism of glucose to CO2 and H2O The oxidation of glucose with organic molecules serving as electron acceptors QUESTION 3 The best definition of osmotic pressure is The active...
Which of the following would result from the action of phospholipase C on a membrane glycerophospholipid? A. Glycerol and two fatty acids B. One fatty acid and one monoacylglycerol C. A sugar phosphate and glycerol D. A lysophospholipid and a diacylglycerol E. A diacylglycerol and a polar group containing phosphate
Most questions answered within 3 hours.
-
A helium balloon with 2.5L of gas has a gauge pressure of 10,000
Pa. The balloon...
asked 18 seconds ago -
What is responsible for Jupiter's enormous magnetic field?
asked 15 minutes ago -
At the end of the year, a company offered to buy 5,000 units of
a product...
asked 17 minutes ago -
Implement C++ program for each of the following.
Let D = [-48, -14, -8, 0, 1,...
asked 37 minutes ago -
Consider a labor market in which LD = 400 – 4W and LS = 250 +...
asked 51 minutes ago -
Let’s say you are teaching a typically-developing young child
how to eat with a spoon. Describe...
asked 34 minutes ago -
Ask Your Teacher A toy gun uses a spring to project a 5.6-g soft
rubber sphere...
asked 46 minutes ago -
*****DO NOT ANSWER THIS QUESTION IF YOU DON'T
KNOW*******
Question - PERSONAL DEVELOPMENT ESSAY and Detailed...
asked 53 minutes ago -
A certain rifle bullet has a mass of 5.25 g. Calculate the de
Broglie wavelength of...
asked 1 hour ago -
Research new software products that assist in project
communication management. Write a paper summarizing your findings,...
asked 1 hour ago -
the figure below to the left shows a beaker completely filled
with water. then a block...
asked 1 hour ago -
what is the duistribution channels of HUL in india and how they
distribute?
how is this...
asked 1 hour ago