Question

Briefly describe your study about candida glabrata. State your hypothesis/research question. Indicate how you intend to answer this question and what are your expected results.

Answer 1

Introduction: Candida glabrata belongs to the class saccharomycetes which comes under the Candida genus.Candida glabrata is a species of haploid yeast and genus Candida. This species has no sexual life. The previous old name for candida glabrata is Torulopsis glabrata. It is usually found in mucosal tissues of humans, mostly in immune deficient persons who are having diabetes, HIV infection, AIDS, etc. It is the common cause of candidiasis, and the infections caused by candida glabrata effects Genito urinary system.

When it is being incubated, a dark green colour colonies occurs. Most of the cells goes in to blood stream which causes infection.Culture is the best method to find out the presence of non albicans genital infections. Culture can take many days to grow up. In the case of skin disease, it is very difficult to find out fungus from swabs, thus special assessment is required in this case. This organism is mainly resistant to fluconazole and echinocandin. Culture is the best method to find out the presence of non albicans genital infections. Culture can take many days to grow up. In case of skin disease, it is very difficult to find out the fungus from swabs. Special assessment is required in this case. This organism is mainly resistant to fluconazole and echinocandin.  

Azole drugs are mostly prescribed for the treatment of this infection because it has low level intrinsic resistance in 15 to 20 % people fluconazole is not effective. Over-the-counter vaginal creams such as clotrimazole (Gyne-Lotrimin) 1% 5 g, or miconazole (Monistat) 2% 5 g, typically used at bedtime for 3 or 7 days. Polyene drugs can use in some cases such as amphotericin and caspofungin, sometimes intravenous or amphotericin is used to treat this condition. Terconazole 7 days cream can be used as it has 40% a chance of recovery. Boric acid can be used as a second line treatment as it is effective for chronic infections. Vitamin E oils and Amphotericin B suppositories to cure both symptomatic and asymptomatic conditions.

During in the pregnancy time and the people who are having immune compromised are diabetics patients are having more prone to get these infections. To prevent this hygienic condition, it should be maintained adequate intake of nutritious diet, genital hygienic, environment maintenance. This organism is resistance to anti-fungal drug like class of azoles.  

Conclusion: These Candida glabrata is like normal flora in the human body , oropharynx, and the intestines. If the people are in immunocompromised state these will cause infection to the persons. We need to educate the maintenance of hygienic conditions of genital and oral cavity etc., then we can prevent the fungal infections by maintaining of oral cleaning with mouth wash and vaginal cleaning with clean warm water. The infective agent causes white, cheesy, thick discharges with burning sensation with intense itching, pruritis is common in vulvar region. The anti-fungal agent act against to this. If once the resistance of drugs happens there is no responding of microorganisms to that drug, so before development of resistance there is a need to maintain preventive measures to avoid getting infections and need to educate about multi drug resistance problems and maintenance of hygiene. These are should be educated as a health care professional.