Question

Discuss the pathogenesis of prostate cancer

Answer 1

In US prostate cancer is reported as 2^nd most common reason of the cancer-associated deaths in the men. The following are the possible causes of the prostate cancer:

• High intake of the saturated fats saturated fat intake
• Vasectomy
• High serum androgen levels
• And family history of the prostate cancer

Out of above high serum androgen level is most common cause of prostate cancer in men, which is governed by the androgen receptor signaling (AR signaling). This is encoded by a gene situated on X-chromosome known as Xq11.2-q12 gene containing poly-glutamine, poly-proline and poly-glycine subunits of the variable lengths. This length of poly-glutamine is associated with the risk of the prostate cancer and its severity. Further in prostate cancer the balance between the prostate cell proliferation and apoptosis is also disturbed.