Question

SEE ACCOMPANYING NDC 0049-0530-28 USUAL DOSAGE Pfizerpen For Injection PATIENT PRESCRIBING INFORMATION. 6 to 40 million units daily by intravenous infusion only Buffered RECOMMENDED STORAGE IN DRY FORM. Asprox onits per L mL dileent 75 mL 11.5mL Store below 86"F(3rc). !(penicillin G potassium), Butfered with sodium citrate and citric acid to optimum pH. 1,000.000 AFTER SOLUTION SHOULD BE REFRIGERATED. DISCARD UNUSED SOLUTION AFTER 7 DAYS ROOM WENTY MILLION UNITS DATE TIME BY 05-4211-00-8 Rx only FOR INTRAVENOUS INFUSION ONLY MADE IN USA 7488 Roerig Division af Pricer InG, NY.NY 3001 Plizer RECONSTITUTION OF MULTIPLE STRENGTH SOLUTIONS 1. If you add 75 mL diluent to prepare a solution, what dosage strength will you print on label? After Pfizerpen is reconstituted with 11.5 mL diluent, a doctor orders 10,000,000 U stat. AddmL to the IV 2. After Pfizerpen is reconstituted with 33 mL diluent, a doctor orders 10,000,000 U stat. Add 3. mL to the IV. the solution, and Based on questions 2 and 3, the more diluent added, the the 4. mL needed to fill a given order. 5. Can Pfizerpen be given IM? 6. Does it need refrigeration? 7. What is its shelf life?

This is what i have so far:

update!

Answer 1

1.Given When 75 ml of diluent is added then =250000 u/ml (1ml=250,000 units)

Ans:The dosage strength which has to be printed on the label is 250,000=1ml (250000/ml)

2.Given

Order=10,000,000 units

Diluent =11.5 ml

Here 11.5 ml=1,000,000 u/ml

Then 10,000,000=??

Cross multiply and divide

(10,000,000×1÷1,000,000=10)

Ans:10ml  to be added to the IV

3.Given

33ml diluent:500,000u/ml (1ml=5,000,000u)

Order:10,000,000 U

Cross multiply and divide

(10,000,000×1÷5,000,000=2)

=2ml to be administered

4.When more diluent is added the solution is weaker and more or increased ml to be administered

5.The label clearly states only IV can be administered and not IM

6.Yes ,after reconstitution the solution should be refrigerated and discarded after 7 days

7.Shelf life refers to the duration of a drug can be used after reconstitution/ dilution/opening. Here the shelf life is 7 days