What is the difference between statistically significant evidence and clinically significant evidence. How would each of these findings be used to advance an evidenced-based practice project?
In clinical research, study results, which are statistically significant are often interpreted as being clinically important. While statistical significance indicates the reliability of the study results, clinical significance reflects its impact on clinical practice.
In clinical practice, the "clinical significance" of a result is dependent on its implications on existing practice-treatment effect size being one of the most important factors that drives treatment decisions. LeFort suggests that the clinical significance should reflect "the extent of change, whether the change makes a real difference to subject lives, how long the effects last, consumer acceptability, cost-effectiveness, and ease of implementation". [2] While there are established, traditionally accepted values for statistical significance testing, this is lacking for evaluating clinical significance. [3] More often than not, it is the judgment of the clinician (and the patient) which decides whether a result is clinically significant or not.
Statistical significance is heavily dependent on the study's sample size; with large sample sizes, even small treatment effects (which are clinically inconsequential) can appear statistically significant; therefore, the reader has to interpret carefully whether this "significance" is clinically meaningful. A study published in the Journal of Clinical Oncology compared overall survival in 569 patients with advanced pancreatic cancer who were randomised to receive erlotinib plus gemcitabine versus gemcitabine alone. [4] Median survival was found to be "significantly" prolonged in the erlotinib/gemcitabine arm (6.24 months vs. 5.91 months, P = 0.038). The P = 0.038 means that there is only a 3.8% chance that this observed difference between the groups occurred by chance (which is less than the traditional cut-off of 5%) and therefore, statistically significant. In this example, the clinical relevance of this "positive" study is the "treatment effect" or difference in median survival between 6.24 and 5.91 months - a mere 10 days, which most oncologists would agree is a clinically irrelevant "improvement" in outcomes, especially when considering the added toxicity and costs involved with the combination.
What is the difference between statistically significant evidence and clinically significant evidence. How would each of...
What is the difference between statistically significant evidence and clinically significant evidence? How would each of these findings be used to advance an evidenced-based project?
What is the difference between statistically significant evidence and clinically significant evidence? How would each of these findings be used to advance an evidenced-based project?
What is the difference between statistically significant evidence and clinically significant evidence? How would each of these findings be used to advance an evidenced-based project?
Can you tell me the difference/s between statistically significant evidence and clinically significant evidence? How would each of these findings be used to advance an evidenced-based project? 2 APA References. Thanks
What is the difference between staristical significance and clinical significance ? Explain why statistically significant results in a study do not always mean that the study is clinically significant . Provide an example .
what is the difference between evidence based practice and practice based evidence
What is the difference between research- and evidence-based practice projects? Provide an example of each one and the reason for the difference. Why should nurses be interested in learning about EBP?
What is the difference between research- and evidence-based practice projects? Provide an example of each one and the reason for the difference. Why should nurses be interested in learning about EBP?
Dr. Cribari would like to determine if there is a statistically significant difference between her two Math 2830 classes. To make this comparison she will compare the results from exam 1. Class one had 35 students take the exam with a mean of 82.6 and a population standard deviation of 1.41. Class two had 32 students take the exam with a mean of 84 and a population standard deviation of 3.63. Can Dr. Cribari conclude that there is difference in...
What is the difference between research and evidence-based practice (EBP) projects? Provide an example of each one and the reason for the difference. Why should health care workers be interested in learning about EBP?