Question

Compare and contrast the MMR vaccine with three other vaccines. When comparing vaccines, consider therapeutic action, pharmacokinetics, contraindications, most common adverse reactions, and important drug-drug interactions. (Learning Objective

Answer 1

	MMR vaccine	Poliovirus	DPT
Therapeutic action	It is live attenuated vaccine protect against measles, mumps, and rubella by stimulating the immune system.	It is effective against poliomyelitis.	It protects against diphtheria, pertussis, and tetanus.
Pharmacokinetics	It consists of highly purified gelatin, sorbitol, polysorbate, and serum albumin. The peak onset is unknown.	Response to vaccine within 7 to 10 days.	It is an attenuated vaccine consists of antigenic material to stimulate the immune system. Onset on 2 week and effective for 4 - 6 years.
Contraindications	Immunosuppressed, cancer, untreated tubercluosis patient.	Allergic to polio drops, and immunosuppressed patients.	Allergic to previous dose, nervous problem, coma, Guillain Barre syndrome.
Adverse reactions	Soreness around the shot, swelling, temporary pain, stiffness of the muscles, rash, fever.	Tiredness, nausea, headache, sore throat, fever.	Redness, soreness, swelling, fever, vomiting, lowered consciousness, anorexia.
Drug to Drug interaction	Interfere with other vaccines, medications and lead to severe anaphylactic reactions.	Interact with streptomycin, neomycin.	Interfere with atorvastatin, baclofen, bupropion, levothyroxine.