Question

PATH370 2018 WEEK 2 TOPICS ICH 10, 11, 13, 14) IMMUNE SYSTEM REVIEW-USE PPTS, TEXTBOOK, AND ANATOMY/PHYSIOLOGY MATERIALS - 4 major signs/symptoms of inflammation and what causes each to occur - role of chemotaxis - diagnostic tests indicative of inflammation - acute vs chronic inflammation end result of chronic inflammation - functions of all types of WBCS CHAPTER 10: ALTERATIONS IN AMMUNE FUNCTION - autoimmunity: describe what is going wrong with the immune system and give examples - define MHC and HLA, Identity where they are located and give their function define autoantibodies and antinuclear antibodies (ANAS), and indicate what they each attack - pender more frequently affected, tripers for onset of autoimmunity general treatment options - hypersensitivity: describe what is going wrong with the immune system in hypersensitivities -Type t describe hypersensitivity problem, examples/causes, function/role of histamine, clinical manifestations, anaphylactic shock - why is anaphylaxis life-threatening? what needs to be administered immediately? why? Type : describe hypersensitivity problem blood type that is universal donor? universal recipient? why? - erythroblastosis felis common name, when/Why does it occur, RhoGAM Type : describe hypersensitivity problem - systemic lupus erythematosus (SLE): describe, systems/organs affected, why is it difficult to diagnose, labresults - Type IV:describe hypersensitivity problem, give examples what is Mantoux skin test and how does it work? how long does it take to appear? immunodeficiency disorders: primary vs secondary, examples of each CHAPTER 11: MALIGNANT DISORDERS OF WHITE BLOOD CELLS - Overview of WBC cancers: - leukemia vs lymphoma vs myeloma (in general) typical signs/symptoms of WBC cancer; what typically causes death to finally occur in these patients? possible cause, common complications, main treatment methods - explain why a bone marrow transplant would be needed:autologous vs allogeneic transplants - acute lymphoblastic leukemia -cell types affected, age at ont, fast/acute or slow/Insidious onset - clinical manifestations, prognos survival rate, treatment options - chronic myeloid leukemia -cell types affected, age at one type of acute or insidious), impact on spleen - multiple myeloma: - cell types affected, age at type of acute or insidious), impact on bones and kidneys -Hodgkin vs Non-Hodgkin lymphoma: age at one, gender most often affected - pattern of growth/spread; clinical manifestations, treatment options -type of cancers associated with: Philadelphia chromosome, Reed-Sternberg cell, Bence-Jones protein Epstein-Barr virus

Answer 1

he signSymptoms of inflammation indude paih, heat, redness, swelling and loss of funchon. When the inflamma tion process starts, chemfcals In the mhite blood cells are released into the blood and affected tiscues to protect the body. The chemical increase the blood flon to the infected or injured body areas, causing redness those area. Thece chemicals may ako cause lea fluid into tissues, resul ting protechve process will also stnulate nenves and tissues and warmth In in Swelling. Thi Causing pain. Chemotaxic is directed migration of cells in beponse to concentration radent erhracelllar cignals. The movement of leukoytes rom the Vestel lumen damaged into area is called chemotaxis a

he diagnashic test for Inflammation are D Faeal calprtectin 2) ErH Erythrocyte sedlimentahion rate 3) hs- CRP test Erythem a 5 Cobalamin Acute Inllammation Acute ihlammation may inclu de heat of a fever Acute bronchitis, Which causes inflammation of the oirnays that ca Chronu'c Inflomma tion can occur anywhere in the body and may fngger any humber of chronre diseases, dleperiarng affected Examplesinlammatory arthrit, Asthha periodontiti's or warmth In the affecte area lumgi air to the the bady on tha area o