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How does genetics influence pathophysiological alterations in healing, immunologic responses, and the integumentary system?

How does genetics influence pathophysiological alterations in healing, immunologic responses, and the integumentary system?

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Ans) The integumentary system reflects numerous changes from genetic and environmental factors
- The skin becomes thinner (producing translucent, paper thin quality & more susceptible to tearing)
Drier, wrinkled (loss of elastin)
Demonstrates a change in pigmentation (fewer melanocytes) with decreased protection from UV radiation (Changes in hair color)
- Decrease in DNA repair of damaged skin
- More permeable & less able to clear substances causing irritation
- Loss of flexibility of collagen fibers (cannot stretch & regain shape as readily)
- Increased risk of injury & infection related to reduced barrier function
- Fewer melanocytes and Langerhans cells reducing immune response
- Wound healing decreases related to decreased blood flow & slower basal cell turnover
- Atrophy of the sebaceous, eccrine, and apocrine glands causing dry skin
- Fewer hair follicles and growth of thinner hair
- Pressure, touch, receptors & free nerve endings decrease in number causing reduced sensory perception
- Compromised temperature regulation, loss of cutaneous vasomotion, & decreased eccrine sweat production = increased risk of heat stroke /hypothermia

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