Question

options from left to right

first line is

a a

secound line options from left to right

Aa aa AA Aa aa

third line options from left to right

AA. aa Aa AA aa

W4 Quiz 6. Inheritance patterns in humans Achondroplasia is an autosomal dominant disorder that affects skeletal growth and results in a greatly reduced stature. The presence of the achondroplasia allele causes a condition sometimes referred to as "dwarfism (although it is important to note that it is not the only cause of dwarfism; many other genes and biological factors can cause dwarfism as well). Achondroplasia occurs only when a person is heterozygous for the allele. For reasons still unknown, being homozygous dominant for the achondroplasia allele is fatal. Embryos that are homozygous dominant frequently miscarry or are stillborn. Heterozygous individuals survive to birth but are affected with achondroplasia throughout their entire life. Imagine you are a genetic counselor advising a young couple who want to have a child together. The man has achondroplasia, but the woman does not. Complete the Punnett square to see their possibilities for allele inheritance. (Note: The father's genotype has already been filled in for you. Complete the mother's genotype at the top of the square, and remember that dominant alleles are always listed first.) Then use the Punnett square to answer the question. What is the probability that a fetus they conceive will miscarry because it is homozygous dominant? O 0% 100%

Answer 1

Achondroplasia - Autosomal Dominant AA Aa ala Diseased Diseased Normal (Normal) Mother aa father (A chondroplasia) "Aa (given) a a Aas Diseased (Heterozygous Dominant) La aa Normal The Progeny will not show homozygous Dominant Genotype So, the probability that a fetus they conceive will miscarry because it is homozygous dominant is 0%.