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Gene A is regulated by DNA binding transcription factors encoded by genes B, C, and D....


Gene A is regulated by DNA binding transcription f
Gene A is regulated by DNA binding transcription factors encoded by genes B, C, and D. Genes B and C encode transcriptional repressors and gene D encodes a transcriptional activator.
1) Diagram what the expression pattern of gene A would be:
a) in embryos that are homozygous for a null mutation in gene B.
b) in embryos that are homozygous for a null mutation in gene C.
c) in embryos that are homozygous for a null mutation in gene D.
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Answer #1

A null mutated alleles completely lack their normal function.

a. given diagram shows that the expression of gene A is equal to expression of gene D (activator) minus expression of gene B and C (repressor) i.e A= D - (B + C). Thus, If gene B is null mutated then the expression of gene A will increase to equal amount of gene B (New expression pattern of gene A= A + B)

b. Similarly for null mutation of gene C, The new expression pattern of gene A= A+C

c. the null mutation of gene D cause completely lack of activator thus the expression of gene A reduce to almost null.

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