Grignard reaction What is the purpose of adding anhydrous MgSO4 to the ether solution? What would...
Grignard reaction What is the purpose of adding anhydrous MgSO4 to the ether solution? What would occur if this step were omitted?
Homework Answers
Anhydrous MgSO4 is used to dry ether layer to allow better handling. If we did not use anhydrous MgSO4 our product could ionize.
or
after completion of grignard reaction, we have added ether to dissolve the product to seperate it from all the inorganic substaces. At that point the ether has a little dissoved water in addition to the product. If we evaporate the ether to recover the product there willl be moisture in whatever solid or liquid it is. Moisture may hydrolyse the product during the heating needed to recyrstalise or distill it. Anhydrous MgSO4 absorbs moisturenform the ether without reacting any thing.
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Grignard reaction What is the purpose of adding anhydrous MgSO4
to the ether solution? What would...
A Grignard reaction was performed using the following steps: Step 1: Addition of Grignard Reagent: Phenyl...
A Grignard reaction was performed using the following steps: Step 1: Addition of Grignard Reagent: Phenyl Magnesium Bromide a solution of phenyl magnesium bromide (2.7 mL of a 3.0 M solution in anhydrous diethyl ether) and 5 mL of anhydrous diethyl ether was dispensed into the round-bottom flask and stirred with a stir bar. Step 2: Addition Formation: Reaction with Benzophenone A solution of 0.72 g (mp = 48-49 degrees C) of benzophenone and 2.0 mL of anhydrous diethyl ether...
What is the purpose of adding 50% sodium hydroxide solution in Wittig reaction.
Question 13 What is the purpose of adding 50% sodium hydroxide solution in Wittig reaction. A) reactant B) recrystallization C) deprotonation D) Solvent Question 14 What is the purpose of anhydrous calcium chloride pellets in wittig reaction. A) Drying aqueous layer B) Reactant C) Reagent D) Drying organic layer Question 15 Provide the structure of the ylide needed to prepare 3-ethyl-3-heptene from 3-pentanone using a Wittig reaction.
2. Predict the product and draw the mechanism for the Grignard reaction shown in the video....
2. Predict the product and draw the mechanism for the Grignard reaction shown in the video. Show all electron pairs that participate in the reaction, electron flow arrows, and intermediates. Write a paragraph describing what is happening during the mechanism. MgBr Ph H 2.NH.Cl(aq) 3. Why must this reaction be done in two steps? (In other words, what would happen in you mixed the carbonyl. Grignard reagent, and the aqueous ammonium chloride all together?) 4. In this reaction NHCI was...
What is the mechanism for the gringard feaciton between: magnesium and bromoethane (with anhydrous ether—whats the...
What is the mechanism for the gringard feaciton between: magnesium and bromoethane (with anhydrous ether—whats the purpose of this??) Then, after the magensium is finished reacting benzophenone is added with anhydrous ether. After seperation, HCl and ice water are added. The ether layer should seperate containing the solid Carbinol product Can you show me the steps to this reaction?
Grignard Reaction with a Ketone: Triphenylmethanol Introduction: The purpose of this lab is to prepare phenylmagnesium...
Grignard Reaction with a Ketone: Triphenylmethanol Introduction: The purpose of this lab is to prepare phenylmagnesium bromide, a Grignard reagent, and react it with benzophenone to give triphenylmethanol. Grignard reagents are very reactive and must be synthesized in an environment free of water or any other source of potential proton donor. Once made, the Grignard reagent will do a nucleophilic attack on the carbonyl carbon of the ketone, benzophenone. The result is an alkoxide that is then protonated to give...
Grignard reagent THE GRIGNARD REAGENT-PREPARATION AND REACTION In this experiment, you will prepa...
i need help with the prelab questions please
Grignard reagent THE GRIGNARD REAGENT-PREPARATION AND REACTION In this experiment, you will prepare a Grignard reagent, phenyl magnesium bromide, from bromobenzene and magnesium metal. The Grignard reagent will then react with methyl benzoate to form triphenylmethanol. Introduction Grignard reagents, such as organomagnesium halides, were discovered in 1910 by French chemist Victor Grignard. The Grignard reaction is one of the most general methods for carbon- carbon bond formation in all of organic chemistry....
What is the purpose of extracting the aqueous layer two more times with ether in step...
What is the purpose of extracting the aqueous layer two more
times with ether in step 5?
What is the purpose of washing the combined organic layers with
NaOH in step 6?
Thank you
Reaction 1: Nitration HNO3 NO2 + H2SO4, H20 NO2 toluene NO2 ortho meta para Procedure for Reaction 1: 1) To a stirred solution of 3 ml (44.7 mmoles) 67 % HNO3 in 3.75 mL of water, H2SO4 (9 mL) was slowly added at 10-15 °C. 2)...
MgBr + anhydrous ether Mg MW: 24.31 Grignard reagent MW: 157.02 R-X + Mg - R-X...
MgBr + anhydrous ether Mg MW: 24.31 Grignard reagent MW: 157.02 R-X + Mg - R-X + Mga Single Electron Transfer (SET) R-X - R + X- R + Mg - RM RMG + X- RMX Ph MgBr Ph Lo MaBr H (Ph)3COH Pn H20 MW:260.34 Grignard reaction • Volume of bromobenzene is 4.5 mL. • Density of bromobenzene is 1.5 g/ml • Mass of benzophenone is 6.75g • We assume 65% yield of the product (triphenylmethanol) was obtained in...
4. what is the purpose of adding the anhydrous sodium sulfate to GC-MS vial and filtering...
4. what is the purpose of adding the anhydrous sodium sulfate to GC-MS vial and filtering it? what might happen during the GC-MS analysis if we didn't perform these steps?
Abbutie uit water and your solvent of interest are not miscible. 2. What is the purpose of adding anhydrous CaCl, (...
Abbutie uit water and your solvent of interest are not miscible. 2. What is the purpose of adding anhydrous CaCl, (or MgSO.) to the dichloromethane?
2. Predict the product and draw the mechanism for the Grignard reaction shown in the video. Show all electron pairs that participate in the reaction, electron flow arrows, and intermediates. Write a paragraph describing what is happening during the mechanism. MgBr Ph H 2.NH.Cl(aq) 3. Why must this reaction be done in two steps? (In other words, what would happen in you mixed the carbonyl. Grignard reagent, and the aqueous ammonium chloride all together?) 4. In this reaction NHCI was...
i need help with the prelab questions please
Grignard reagent THE GRIGNARD REAGENT-PREPARATION AND REACTION In this experiment, you will prepare a Grignard reagent, phenyl magnesium bromide, from bromobenzene and magnesium metal. The Grignard reagent will then react with methyl benzoate to form triphenylmethanol. Introduction Grignard reagents, such as organomagnesium halides, were discovered in 1910 by French chemist Victor Grignard. The Grignard reaction is one of the most general methods for carbon- carbon bond formation in all of organic chemistry....
What is the purpose of extracting the aqueous layer two more
times with ether in step 5?
What is the purpose of washing the combined organic layers with
NaOH in step 6?
Thank you
Reaction 1: Nitration HNO3 NO2 + H2SO4, H20 NO2 toluene NO2 ortho meta para Procedure for Reaction 1: 1) To a stirred solution of 3 ml (44.7 mmoles) 67 % HNO3 in 3.75 mL of water, H2SO4 (9 mL) was slowly added at 10-15 °C. 2)...
MgBr + anhydrous ether Mg MW: 24.31 Grignard reagent MW: 157.02 R-X + Mg - R-X + Mga Single Electron Transfer (SET) R-X - R + X- R + Mg - RM RMG + X- RMX Ph MgBr Ph Lo MaBr H (Ph)3COH Pn H20 MW:260.34 Grignard reaction • Volume of bromobenzene is 4.5 mL. • Density of bromobenzene is 1.5 g/ml • Mass of benzophenone is 6.75g • We assume 65% yield of the product (triphenylmethanol) was obtained in...
4. what is the purpose of adding the anhydrous sodium sulfate to GC-MS vial and filtering it? what might happen during the GC-MS analysis if we didn't perform these steps?
Abbutie uit water and your solvent of interest are not miscible. 2. What is the purpose of adding anhydrous CaCl, (or MgSO.) to the dichloromethane?
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