Question

ABC transporters are responsible for most drug resistance found in cancers. They use ATP hydrolysis to pump smallmolecules like drugsoutside of the cellOne anti-cancer drug that is exported from the cell by these pumps is doxorubicin (shown below).I know it says "Shown below" but there is no diagram of Doxorubicin for this question

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Answer #1

doxorubicin acts as anticancer agent by interfering with the DNA function by blocking the enzyme called topoisomerase 2 ( which is useful for supercoiling of DNA during the transcription process ) and it is acting by both intracellular and extracellular mechanisms for acting through extracellular mechanism it requires 70mM concentration

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