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What is meant when you say that a bacterial population is tolerant to antibiotics? What is...

What is meant when you say that a bacterial population is tolerant to antibiotics?

What is the significance of antibiotic tolerance for individuals who take antibiotics against infections?

Can antibiotic tolerance have any importance for the development of antibiotic resistance? Why / Why not?

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Answer #1

a) Antibiotic tolerance is a temporary and reversible physiological state of a small population of bacteria or microbes. They live in a dormant state which enables them to survive the antibiotics killing for a certain duration of time. They are not genetically mutant unlike the antibiotic resistance bacteria. So such a population is called antibiotic tolerant bacterial population.

b) When an individual with antibiotic tolerant bacteria takes antibiotics he may temporarily get rid of his phenotypic symptoms but it will reappear again and may develop into chronic infections because these tolerant bacteria can survive the antibiotic treatment for a certain duration of time.

c) Yes, antibiotic tolerance has a significant role in the development of antibiotic resistance because after several cycles of antibiotics exposure the tolerant bacteria naturally develope some mutations in their genome and this makes them antibiotic resistance. Hence antibiotic tolerance leads to antibiotic resistance microbes.

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