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How to prevent the potential inflammation caused by the degradation byproducts of lactic and glycolic acid?

How to prevent the potential inflammation caused by the degradation byproducts of lactic and glycolic acid?

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Poly lactic acid-glycolic acid (PLGA) has got much importance in dentistry. However, the degradation products of PLGA i.e.lactic and glycolic acid can decrease the pH in the surrounding tissues and cause inflammation.The cell adhesion of these products can be reduced by using hydrophobic bioresorbable polyesters. Incarporation of different nanoparticles such as titanium nanoparticles, tripolyphosphate nanoparticles, nanoapatite particles, PLGA layers coated with apatite layer etc. decreases the occuance of inflammation.

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