For Dieckmann condensation there is need for at least two alpha hydrogen atoms. So that base abstract second proton and equilibrium will be shifted in the forward direction.
Each compound below undergoes a Dieckmann Condensation (Intramolecular Claisen). Predict the major product(s) for each. Some...
Predict the major product formed when the compound shown below undergoes a Dieckmann condensation with CH3ONa in CH3OH, followed by acidic workup. Part A Predict the major product formed when the compound shown below undergoes a Dieckmann condensation with CH3ONa in CH30H, followed by acidic workup nteractive 3D display mode H3C
Part A Predict the product formed when the compound shown below undergoes Claisen condensation followed by acidic workup. (The product incorporates two equivalents of the starting material.) Interactive 3D display mode ҫн, о H,с ОМe Draw the molecule on the canvas by choosing buttons from the Tools (for bonds), Atoms, and Advanced Template toolbars. The single bond is active by default.
Predict the major product of the following Claisen condensation 1.NaOMe 2. H2O+ Meo OOH Med a ver C B Both B&D OD
6. Give all possible structures of the product (C20H1203) formed by intramolecular Claisen condensation of the keto-ester shown below. 1. NaOH 2. H,0
Provide the reactants that would give the following aldol condensation products Predict the major product or provide the missing reagent for the following Claisen Condensation reactions
The following compound undergoes an intramolecular Robinson annulation reaction consisting of a conjugate addition followed by an aldol condensation. Draw the final product. No mechanism needed. Question 3 ( 5 points ) СН3 HO molargla H3C Create OscerSketch Answer 3 Question 4 Predict the product of the following reaction sequence. Draw the single main product structure only. ( 5 points ) H3C LDA (acid workup) Create OscerSketch Answer 4
7. Predict the major organic product or provide reagents needed to complete each reaction. 1. CH3NH2 (a-b) excess 2. LIAIHA 3. H20 ia -NH ?? excess (c-d) HO NH2 triethylamine ? (e-f) CEN 1. CHẠMgBr 2. H20, H NH2 (g-h) H20, H* H2. Pd (1-1) CH3NH2 4 products (m) 1. LAIH 2. H2O, H & NH (n) 1. LiAIH4 2. H20, H+ 8. Predict the four possible Aldol condensation products and their dehydration products. KOH, H20.A + H 1. Predict...
6) Predict the major product in each of the following reactions and indicate if it came from an Sn1, S2, E1, or E2 reaction. H3C Br NaOme CH3 H2O H Br MeOH 'BUOK H Br DMSO H3C Br NaOme CH3 H20 MeOH H OTS ЕКОН
1. What is the major organic product obtained from the following intramolecular aldol condensation reaction? NaOH, HẠO . 1 b. 2 . 3 d. 4 2. What is the major organic product obtained from the following intramolecular Claisen Condensation (Diepkova ) reaction? مع عمه Baraeenie Product onlained from ( 1. NaOCH2CH3 CH3CH2OH CH3CH30 OCH2CH3 2. H30+ OCH CHE OCH2CH3 مسلسلا سلال OCH2CH3 OCH2CH3
3. For each of the reactions shown below, predict the single major product and determine which mechanism, S1, Sh2, E1, or E2, is operative. Briefly justify your choice. Be sure to indicate stereochemistry in the product if it is relevant s Ko'Bu BUOH C. conc. H2SO4 d. [1 equiv ) NaOMe Br MeOH