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Which of the following can lead to p53 stabilization and activation? Hypoxia Overexpression of Myc DNA...
Why do loss of function mutations in p53 often lead to mutations in other genes? See Section 19.6 (Page) O p53 normally functions as a tumor suppressor to stop the cell cycle after DNA damage occurs. O p53 normally functions as a tumor suppressor that encourages cell growth by triggering specific phases of the cell cycle O p53 normally functions as a proto-oncogene to stop the cell cycle after DNA damage occurs. O p53 normally functions as a proto-oncogene that...
DNA does not code for lipids. In spite of this, gene activation can lead to a change in the fluidity of plasma membranes as an organism acclimatizes to a drop in temperature. Explain how this is possible.
) is a common type of DNA damage that, if not repaired, can lead to the loss of a nucleotide and possibly a shift in the reading frame. O Depurination Deamination
Which event may lead to cancer? Select all that apply. A. gene mutation B. functioning p53 protein C.Rb protein phosphorylating D. Improper replication of DNA during synthesis E. faulty DNA repair Mark for Review What's This?
help me with that please this question is cery important i have a final , 7. Loss-of-function mutations in p53 typify the ajority of human cancers Discovery of the roles for p53 in the DNA damage checkpoint and in apoptosis helps to explain its potency as a tumor suppressor protein. Recent studies suggest that p53 may possess an additional anti-tumor function: preventing telomerase activity. In one such study by Ogawa and colleagues, a human pancreatic cell line called MIA PaCa-2,...
In contrast to histone acetylation, which always correlates with gene activation, histone methylation can lead to either transcriptional activation or repression. How do you suppose that the same modification - methylation - can mediate different biological outcomes? Explain what is meant when we say two DNA sequences are 'highly conserved'. Why are some sequences conserved and others aren't? In your own words, explain what is meant by "position effect". What is the molecular basis of this phenomenon?
Which of the following would not normally lead to stabilization of a carbocation? Through space inductive effects Polarizability Torsional strain Hyperconjugation Through bond inductive effects Resonance delocalization
Question 1 Which of the following statements is true? Promoter bashing can lead to increased DNA methylation. Methyl groups are removed from the DNA by DNA methyltransferase. ODNA methylation is directly passed on during meisos to all daughter cells. Monoallelic gene expression occurs when a mutation results in dominant gene expression. Patterns of DNA methylation are preserved in somatic cells following mitosis.
How can you generate a mouse that expresses a gene on demand as an adult mouse. none of the above using a tissue specific promotor to drive expression of a tetracycline response element and ubiquitous promotor to control expression of the gene of interest with lots of training using a tissue specific promotor to drive expression of a tetracycline reregulatory protein and a tetracycline response element to control expression of the gene of interest that is driven by a ubiquitous...
Part A Evaluate each of the following defects. Which could lead to uncontrolled growth in cancer? Select all that apply. The overexpression of G1 cyclin. A nonfunctional Rb protein. 0 The overexpression of MPF activity. A nonfunctional E2F protein.