Part A Evaluate each of the following defects. Which could lead to uncontrolled growth in cancer?...
Question 35 (1.5 points) Which of the following does NOT lead to cancer formation? mutant proto-oncogenes mutant tumor suppressor genes passenger mutations mutant Rb Question 36 (1.5 points) The Cdk/cyclin complex can trigger cell division by removing Rb from E2F fixing damaged DNA O
Uncontrolled growth is a necessary step for the development of all cancers. Which of the following drugs, that target the MAP/ERK pathway (EGF receptor pathway), could inhibit uncontrolled cell growth? Drugs that bind and activate the EGF receptor Drugs that inactivate protein kinase A (PKA) Drugs that block the phosphorylation of Mek Drugs that block the inactivation of the RAS g-protein
Which of the following could cause a lymphoma? Choose ONE of the below and explain your choice in 2-3 sentences. Explanation 1: A mutation in the Rb gene causing a single amino acid change in the Rb protein that prevents it from being recognized by Rb kinase Explanation 2: A mutation that causes p53 to be constitutively expressed Explanation 3: An incorrectly spliced transcript from the E2F gene that results in an early stop codon in the mature mRNA Explanation...
Which event may lead to cancer? Select all that apply. A. gene mutation B. functioning p53 protein C.Rb protein phosphorylating D. Improper replication of DNA during synthesis E. faulty DNA repair Mark for Review What's This?
There are many forms of cancer, all of which involve abnormal cell growth. The growth and production of all, cled cell proliferation, known to involve anonyme called protein farnesyltransferase ( P ase). It is thought that inibitors of PFTase may be useful as anticancer drugs. The following molecule showed moderate activity as a potential Plase Inhibitor. Draw all stereoisomer(s) of this compound. OOH HOTO
which of the following could be an effective method to suppress tumor growth in a patient? (Select all that apply) C. Developing cancer reagents that promote insulin signaling to the cell would be beneficial because it would inhibit the cell's ability to take in glucose B. Developing cancer reagents that promote the TCA cycle would be beneficial because it could diminish the Walberg effect O D. Developing cancer reagents that inhibit pyruvate kinase would be beneficial because it inhibits glycolysis...
Which of the following could lead a mutation to express a dominant phenotype? Check all that apply. The affected gene is haploinsufficient Both mutant and wildtype alleles are expressed in parallel in the phenotype The mutant protein interferes with the function of wildtype protein The affected gene is haplosufficient
Which of the following could lead a mutation to express a dominant phenotype? Check all that apply. A) Both mutant and wildtype alleles are expressed in parallel in the phenotype B) The mutant protein interferes with the function of wildtype protein C) The affected gene is haploinsufficient D) The affected gene is haplosufficient
Which of the following could you target with RNAi to either reduce cell growth or prevent genome instability to treat cancer? Select all that apply. RasGAP RasGEF Ras Normal Her-2 RTK Her-2 permanent dimer Her-2 lacking ligand binding domain Her-2 lacking kinase domain Ku70/Ku80 Rad51 MDM2 ATM P53
Which of the ONE following characteristic is usually NOT TRUE of cancer cells and the tumors that result? (i.e. all of the answers below are correct except for one-- select the incorrect answer!) Cancer cells do not migrate within the body. Cancer is usually caused by multiple acquired mutations. Cancer cells evolve over time--becoming more potent and more deadly. Cancer cells have dysregulated (uncontrolled) cell division activity. Some cancers are preventable. Question 9 (4 points) Which of the following of...