Uncontrolled growth is a necessary step for the development of all cancers. Which of the following...
Uncontrolled growth is a necessary step for the development of all cancers. Which of the following drugs, that target the MAP/ERK pathway (EGF receptor pathway), could inhibit uncontrolled cell growth?
Drugs that bind and activate the EGF receptor
Drugs that inactivate protein kinase A (PKA)
Drugs that block the phosphorylation of Mek
Drugs that block the inactivation of the RAS g-protein
Homework Answers
MEK phosphorylate and activates nitrogen activated protein kinase which regulates the expression of genes and proliferation. MEK itself is activated by the RAF kinase by phosphorylation. Anticancer drugs like sorafenib inhibits Raf kinase hence inhibit the activation of MEK which prevents the proliferation of cells.
Hence the option C (drugs that blocks the phosphorylation of MEK ) is correct answer.
Add Answer to:
Uncontrolled growth is a necessary step for the development of
all cancers. Which of the following...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of the...
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of these steps indicates the protein is activated after a GTP exchange step? B. (3pts) Which of these proteins can be deactivated by phosphatases? C. (4pts) Describe a mutation that would cause Ras to be permanently "on"? Would this mutation lead to high...
Data List 1. Neural Growth Factor (NGF) is a secreted protein 2. P-STAT has a DNA...
Data List 1. Neural Growth Factor (NGF) is a secreted protein 2. P-STAT has a DNA binding site 3. Erk lives in the cytosol 4. P-Erk lives in the nucleus 5. Ras (which is a completely different protein than Ras-GEF) is a GTPase switch so on with GTP and off with GDP 6. Ras-GDP is located at the plasma membrane 7. TrkA has an amino acid that can have a phosphate group added to it (a phosphorylation site) 8. TrkA...
Pls give short answers. Thank you Q5 EGF pathway 23 Points A EGF EGFR GRB2 SOS...
Pls give short answers. Thank you
Q5 EGF pathway 23 Points A EGF EGFR GRB2 SOS KRAS Active RAS KRAS GOP GDP GTP RAF РІЗК MEK АКТ) ERK Growth and Suppression Proliferation of Apoptosis Shown is the EGF signaling pathway. This is a pathway that normally promotes growth during development, and inhibits apoptosis (or programmed cell death). This pathway is also involved in cancer. Epidermal growth factor (EGF) binds to its receptor (EGFR). This binding activates the protein KRAS, which...
14. You are studying a newly discovered growth factor. You find that this growth factor stimulates...
14. You are studying a newly discovered growth factor. You find that this growth factor stimulates the proliferation of cells grown in the laboratory. You have also found that the receptor that binds the growth factor is a receptor kinase that activates Ras, which activates the MAP kinase pathway. Which mutations affecting this growth factor pathway would you expect to promote uncontrolled cell proliferation? Select all that apply. A. a mutation that inactivates the phosphatase that dephosphorylates the activated receptor...
QUESTION 1 When cells stimulate other cells at long distances, it is referred to as: paracrine...
QUESTION 1 When cells stimulate other cells at long distances, it is referred to as: paracrine loops autocrine loops synaptic signaling endocrine signaling 1 points QUESTION 2 What region of a protein binds phosphorylated serines & tyrosines on another protein? SH2 domain ligand cAMP receptor monomers 1 points QUESTION 3 Activation of a serpentine receptor can lead to: cAMP generation GTP-binding of G proteins activation of Protein Kinase A all of the above 1 points QUESTION 4...
I'd like to ask the answers for all of the uestions Question 1. A reaction in...
I'd
like to ask the answers for all of the uestions
Question 1. A reaction in an anabolic pathway in a cell has a AG of +2.5 kcal/mol. Which of the following is true regarding this reaction? A. It will occur spontaneously. B. The product of the reaction has a lower free energy than the reactants. C. It can occur if it is coupled to ATP hydrolysis. D. It is an exergonic reaction. E. It is breaking a polymer into...
QUESTION 1. Which of the following is produced by the cells of the Zona Glomerulosa? Group...
QUESTION 1. Which of the following is produced by the cells of the Zona Glomerulosa? Group of answer choices Mineralocorticoids Glucocorticoids Glucagon T3 & T4 DHEA Question 2 During which phase of the cardiac cycle would you expect the pressure in the left ventricle to rise above the pressure in the aorta? Group of answer choices Isovolumetric filling Ventricular diastole Atrial systole Isovolumetric relaxation Isovolumetric contraction Question 3 Which hormone increases both Glycogenolysis and Gluconeogenesis? Group of answer choices DHEA...
1. According to the paper, what does lactate dehydrogenase (LDH) do and what does it allow...
1. According to the paper, what does lactate dehydrogenase
(LDH) do and what does it allow to happen within the myofiber? (5
points)
2. According to the paper, what is the major disadvantage of
relying on glycolysis during high-intensity exercise? (5
points)
3. Using Figure 1 in the paper, briefly describe the different
sources of ATP production at 50% versus 90% AND explain whether you
believe this depiction of ATP production applies to a Type IIX
myofiber in a human....
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of these steps indicates the protein is activated after a GTP exchange step? B. (3pts) Which of these proteins can be deactivated by phosphatases? C. (4pts) Describe a mutation that would cause Ras to be permanently "on"? Would this mutation lead to high...
Data List 1. Neural Growth Factor (NGF) is a secreted protein 2. P-STAT has a DNA binding site 3. Erk lives in the cytosol 4. P-Erk lives in the nucleus 5. Ras (which is a completely different protein than Ras-GEF) is a GTPase switch so on with GTP and off with GDP 6. Ras-GDP is located at the plasma membrane 7. TrkA has an amino acid that can have a phosphate group added to it (a phosphorylation site) 8. TrkA...
Pls give short answers. Thank you
Q5 EGF pathway 23 Points A EGF EGFR GRB2 SOS KRAS Active RAS KRAS GOP GDP GTP RAF РІЗК MEK АКТ) ERK Growth and Suppression Proliferation of Apoptosis Shown is the EGF signaling pathway. This is a pathway that normally promotes growth during development, and inhibits apoptosis (or programmed cell death). This pathway is also involved in cancer. Epidermal growth factor (EGF) binds to its receptor (EGFR). This binding activates the protein KRAS, which...
I'd
like to ask the answers for all of the uestions
Question 1. A reaction in an anabolic pathway in a cell has a AG of +2.5 kcal/mol. Which of the following is true regarding this reaction? A. It will occur spontaneously. B. The product of the reaction has a lower free energy than the reactants. C. It can occur if it is coupled to ATP hydrolysis. D. It is an exergonic reaction. E. It is breaking a polymer into...
1. According to the paper, what does lactate dehydrogenase
(LDH) do and what does it allow to happen within the myofiber? (5
points)
2. According to the paper, what is the major disadvantage of
relying on glycolysis during high-intensity exercise? (5
points)
3. Using Figure 1 in the paper, briefly describe the different
sources of ATP production at 50% versus 90% AND explain whether you
believe this depiction of ATP production applies to a Type IIX
myofiber in a human....
Most questions answered within 3 hours.
-
Before practicing a routine on the rings, a 64.8 kg gymnast
hangs motionless, with one hand...
asked 56 seconds from now -
If the K b of a weak base is 6.3 × 10 − 6 , what...
asked 5 minutes ago -
Which of the following is the minimum amount of moles of NaOH
that must be added...
asked 8 minutes ago -
Stories about organizational ________ provide important clues
about cultural values and norms.
a. myths
b. heroes...
asked 10 minutes ago -
Explain the criteria used in selecting a target market
BUS220 Retail Management, thank you!
asked 12 minutes ago -
Convert/Calculate the following:
Determine the identity of an elemental gas if 4.55 L weighing
35.4g, under...
asked 15 minutes ago -
Consider the equilibrium C(s)+ CO2(g) ⇌2 CO(g)
A 2.0 L flask contains a mixture of 0.10...
asked 14 minutes ago -
MATLAB
Part 1 – randFloatValue.m This function accepts two numbers,
lower and upper, and returns a...
asked 20 minutes ago -
You have been asked to hide prizes around your house for your
3-year old nephew. His...
asked 21 minutes ago -
Ammonia will decompose into nitrogen and hydrogen at high
temperature. An industrial chemist studying this reaction...
asked 28 minutes ago -
10. Complete the table below
only using hexadecimal numbers:
AL CODE
EBX
EAX
[EAX]
mov eax,...
asked 46 minutes ago -
trust is best established through the combination of ------and
------- .
1. magnanimity and justice
2....
asked 1 hour ago