Depurination
Depurination is a kind of mutation that involves loss of pruine bases from the DNA like removal of adenine and/or guanine. Frameshift mutation occurs when a particular nucleotide is removed from the DNA strand. This causes the entire follow up nucleotides to undergo mutation and change the nucleotide rearrangements. Depurination causes removal of the purine and if the damage is not repaired, absence of a purine would cause an error in base pairing and the whole frame of the DNA strand having the mutation will undergo a change.
) is a common type of DNA damage that, if not repaired, can lead to the...
Question 1 1 pts Primase is accurate than DNA polymerase at copying a DNA template. more less Question 2 1 pts J is a common type of DNA damage that, if not repaired, can lead to the loss of a nucleotide and possibly a shift in the reading frame. Depurination Deamination Question 3 1 pts Each time the genome is replicated, half the newly synthesized DNA is stitched together from Okazaki fragments. True False Question 4 1 pts The complement...
Repair of DNA damage from UV radiation DNA damage from UV radiation needs to be repaired if DNA replication occurs without error. the following plot shows how cell survival is affected in the presence of UV radiation. Notice that the wild-type cells can overcome the damaging effects of UV radiation on DNA and show high survival even as UV increases. However, cells deficient in certain genes display relatively much lower survival rates. 1. the fact that the double mutant shows...
Discuss the following statement: The DNA repair enzymes that correct damage introduced by deamination and depurination must preferentially recognize such defects on newly synthesized strands.
2. Oxidation of nitrogenous bases is one type of DNA damage. a. What is the most common mechanism for repairing oxidized bases? (1 mark) b. Outline the steps involved in the mechanism you listed in part (a). (3 marks) C. How is this mechanism able to repair other types of damaged bases (for example, deamination of cytosine)? (1 mark)
What are the potential consequences of un-repaired DNA damage (i.e. mutations) (select all that apply)? A. Mutations are always detrimental B. Mutations are always beneficial OC. Somatic mutations lead to cancer or other disease in the affected individual ONLY D. Germ line mutations lead to cancer or other disease in the affected individual ONLY E. Germ line mutations lead to changes in fitness for the affected individual ONLY OF. Somatic mutations lead to changes in fitness for the progeny OG....
Mutation after replication if not repaired Induced mutations Mutagens Nitrous acid Type of damage caused causing bulky Benzo(A)pyrene Aflatoxin B1 Mutation after replication if not repaired Induced mutations Mutagens Nitrous acid Type of damage caused causing bulky Benzo(A)pyrene Aflatoxin B1
Question 3 3 pts Which statement is wrong about cyclobutane thymine dimmer. caused by UV damage. can be repaired by nucleotide excision repair (NER). repaired by base excision repair (BER) can be repaired by DNA photolayse.
Which of the following can lead to p53 stabilization and activation? Hypoxia Overexpression of Myc DNA damage Telomere loss
QUESTION 7 What are the potential consequences of un-repaired DNA damage (i.e. mutations) (select all that apply)? A. Somatic mutations lead to changes in fitness for the affected individual ONLY B. Germ line mutations lead to cancer or other disease in the affected individual ONLY OC. Somatic mutations lead to cancer or other disease in the affected individual ONLY D. Germ line mutations lead to generation of new alleles that are passed on to the progeny E. Germ line mutations...
In order for a cell to move past the G2 checkpoint and into M phase, the cell has to check for which of the following? A All of the DNA has been replicated B. All of the DNA damage has been repaired c. All of the chromosomes are attached to the mitotic spindle D. A and B only E. All of the above (A, B, and C) What type of DNA damage can result in a base loss? A deamination...